Results 71 to 80 of about 9,483,639 (271)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Evaluation of knowledge with multiple-choice tests: three of four options? Experience with admission examinations to medical and surgical postgraduate studies at University of Antioquia (Medellín, Colombia)

Iatreia, 2015
Introduction: The aim of this study was to evaluate the effect of reducing the number of response options per question on the psychometric indicators of an exam for admission to postgraduate medical studies, at University of Antioquia, in Medellín ...
Salazar Blanco, Olga Francisca, Vélez, Claudia Marcela, Zuleta Tobón, John Jairo   +2 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Using Multiple Choice Questions Written at Various Bloom's Taxonomy Levels to Evaluate Student Performance across a Therapeutics Sequence

INNOVATIONS in Pharmacy, 2011
Objective: To evaluate the results of a prospectively developed plan for using multiple choice questions (MCQs) developed at defined Bloom's levels to assess student performance across a Therapeutics sequence.
Amy M. Tiemeier, Zachary A. Stacy, John M. Burke   +2 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Ideas for Delivering Law-based Multiple Choice Questions in the Classroom

, 2023
Ideas for Delivering Law-based Multiple Choice Questions in the ClassroomIt can be challenging to deliver a large volume of practice multiple choice questions in the classroom environment. In this resource the BBP Law School Training and Development Team
Matthew Roden (17179107), Natasha Saleh (17179108), Ben Ferris (17179104), Nicola Rees (17179098), David Dagnall (17179101)   +4 more
core   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

An Alternative Way Of Using

, 2001
At Wageningen University at the chemistry department we use an exam system with pre-printed answers (de Keizer, 1981). The exam is made up of a number of items. Each item is made up of a stem and a pre-printed amount of alternatives. There is no limit to
Multiple-Choice Questions An, Frans Geurts   +1 more
core  

Using item response theory to explore the psychometric properties of extended matching questions examination in undergraduate medical education [PDF]

, 2005
BACKGROUND: As assessment has been shown to direct learning, it is critical that the examinations developed to test clinical competence in medical undergraduates are valid and reliable. The use of extended matching questions (EMQ) has been advocated to
Tennant, A., Mike Horton, Horton, M., Lawton, G., Tennant Alan, Gemma Lawton, David Andrich, Alan Tennant, Horton Mike, Bipin Bhakta, Lawton Gemma, Bhakta, B., Andrich, D., Bhakta Bipin, Andrich David   +14 more
core   +2 more sources