Results 51 to 60 of about 12,192,482 (236)
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Advances in Mechanical Engineering, 2016 In order to reduce the design variable fluctuations in the multi-objective optimization of the pantograph geometric parameters of electric multiple units, a multi-objective reliability design optimization method was proposed based on the dual response ...
Bingzhi Chen +3 more
doaj +1 more source
Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers
FEBS Letters, EarlyView.Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui +4 more
wiley +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Learning-based ship design optimization approach [PDF]
, 2012 With the development of computer applications in ship design, optimization, as a powerful approach, has been widely used in the design and analysis process.
Philip Sayer +5 more
core +3 more sources
ISPRS International Journal of Geo-Information, 2020 Complex geographical spatial sampling usually encounters various multi-objective optimization problems, for which effective multi-objective optimization algorithms are much needed to help advance the field.
Xiaolan Li +4 more
doaj +1 more source
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Frontiers in Neuroscience, 2007 We present a novel framework for automatically constraining parameters of compartmental models of neurons, given a large set of experimentally measured responses of these neurons.
Shaul Druckmann +5 more
doaj +1 more source
Path optimization of taxi carpooling. [PDF]
PLoS ONE, 2018 The problem that passengers are hard to take taxis while empty driving rate is high widely exists under the traditional taxi operation mode. The implementation of taxi carpooling mode can alleviate the problem in a certain extent.
Changxi Ma, Ruichun He, Wei Zhang
doaj +1 more source