Results 61 to 70 of about 12,192,482 (236)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Efficient Multi-Objective Simulation Metamodeling for Researchers

Algorithms
Solving multiple objective optimization problems can be computationally intensive even when experiments can be performed with the help of a simulation model.
Ken Jom Ho, Ender Özcan, Peer-Olaf Siebers   +2 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Wastewater Treatment Plant Design: Optimizing Multiple Objectives

Proceedings of the 7th International Conference on Operations Research and Enterprise Systems, 2018
The high costs associated with the design of wastewater treatment plants (WWTPs) motivate the research in the area of modelling their construction and the water treatment process optimization. This work addresses different methodologies, which are based on defining and simultaneously optimizing several conflicting objectives, for finding the optimal ...
Denysiuk, Roman, Espírito Santo, I. A. C. P., Costa, Lino   +2 more
openaire   +3 more sources

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Multi-Objective Optimization of Tasks Scheduling Problem for Overlapping Multiple Tower Cranes

Buildings
The scheduling of tower crane operations is a complex process. Overlapping areas between tower cranes often lead to increased collision possibilities, resulting in additional tower crane operation complexity. Single objectives related to time or economic
Yanyan Wang, Wenjie Zhao, Wenjing Cui, Guangqiang Zhou   +3 more
doaj   +1 more source

Multi-Objective Optimization Approach for Placement of Multiple DGs for Voltage Sensitive Loads

Energies, 2017
This paper presents the optimal placement of multiple Dispersed Generators using multi-objective optimization. The optimization is carried out with objectives namely active power loss, reactive power loss, voltage deviation and overall economy. The multi-
Navdeep Kaur, Sanjay Kumar Jain
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Application of Multidisciplinary Design Optimization on Advanced Configuration Aircraft

Journal of Aerospace Technology and Management, 2017
An optimization strategy is constructed to solve the aerodynamic and structural optimization problems in the conceptual design of double-swept flying wing aircraft. Aircraft preliminary aerodynamic and structural design optimization is typically based on
Yalin Pan, Jun Huang, Feng Li, Chuxiong Yan   +3 more
doaj