Results 101 to 110 of about 18,011,088 (290)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

The multi-attribute group decision making method based on the interval grey linguistic variables weighted harmonic aggregation operators

open access: yesTechnological and Economic Development of Economy, 2013
With respect to the characteristics of fuzziness, complexity and uncertainty for many group-decision making problems in real world, the paper proposes a novel method based on the interval grey linguistic variables hybrid weighted harmonic aggregation ...
Fang Jin, Peide Liu, Xin Zhang
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

Decision-making Strategies and Performance among Seniors [PDF]

open access: yes
Using paper and pencil experiments administered in senior centers, we examine decision-making performance in multi-attribute decision problems. We find a significant decline in performance with age due to reduced reliance on common heuristics among our ...
Mikhael Shor   +3 more
core  

Dynamic Multi-Attribute Group Decision Making Model Based on Generalized Interval-Valued Trapezoidal Fuzzy Numbers

open access: yesCybernetics and Information Technologies, 2015
In this paper we investigate the dynamic multi-attribute group decision making problems, in which all the attribute values are provided by multiple decision makers at different periods. In order to increase the level of overall satisfaction for the final
Lin Wei, Yan Guangle, Shi Yuwen
doaj   +1 more source

Multi-agent utility theory for ethical conflict resolution

open access: yesJournal of Telecommunications and Information Technology, 2002
In this paper we try to construct a two-attribute group disutility function for two conflicting decision makers, taking into account the property of utility independence and/or convex dependence between them.
Hiroyuki Tamura
doaj   +1 more source

Fuzzy prioritized operators and their application to multiple attribute group decision making

open access: yesApplied Mathematical Modelling, 2013
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Zhao, Xiaofei, Lin, Rui, Wei, Guiwu
openaire   +2 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Validation of Pre-Adolescent Decision-Making Competence in Turkish students

open access: yes, 2019
The objective of this study was to adapt the Pre-Adolescent Decision-Making Competence Test to Turkish, which was originally developed in English by Weller, Levin, Rose and Bossard (2012) for assessing decision-making competence of children between the ...
Cevik, Yasemin Demiraslan and Dogan, Nuri and Daghan, Gokhan and Mumcu, Filiz Kuskaya and Somyurek, Sibel and Karaman, Haydar
core  

A Multi-Attribute Decision-Making Algorithm Using Q-Rung Orthopair Power Bonferroni Mean Operator and Its Application

open access: yes, 2020
The process of decision-making is subject to various influence factors and environmental uncertainties, which makes decision become a very complex task. As a new type of decision processing tool, the q-rung orthopair fuzzy sets can effectively deal with ...
Zaoli Yang, Bowen Hou, Ping He
core   +1 more source

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