Results 111 to 120 of about 555,141 (330)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Integrated INN-MACONT Framework with Interval Neutrosophic MAGDM: Enhancing Services Performance Evaluation in Library and Information Institutions from the Perspective of User Experience [PDF]

open access: yesNeutrosophic Sets and Systems
From the perspective of user experience, the performance evaluation of services in library and information institutions focuses on the ease of use, satisfaction, and responsiveness to user needs.
Jiaqi Chen, Xiao Liu
doaj   +1 more source

Multiple attribute group decision making based on interval neutrosophic uncertain linguistic variables [PDF]

open access: yesInternational Journal of Machine Learning and Cybernetics, 2015
To deal with decision-making problems with interval neutrosophic uncertain linguistic information, the paper proposes a multiple attribute group decision-making method under an interval neutrosophic uncertain linguistic environment.
openaire   +2 more sources

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

The multi-attribute group decision making method based on the interval grey linguistic variables weighted harmonic aggregation operators

open access: yesTechnological and Economic Development of Economy, 2013
With respect to the characteristics of fuzziness, complexity and uncertainty for many group-decision making problems in real world, the paper proposes a novel method based on the interval grey linguistic variables hybrid weighted harmonic aggregation ...
Fang Jin, Peide Liu, Xin Zhang
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Does the National Institute for Health and Clinical Excellence take account of factors such as uncertainty and equity as well as incremental cost-effectiveness in commissioning health care services? A binary choice experiment [PDF]

open access: yes
Background: NICE is an independent organisation responsible for providing national guidance on the promotion of good health and the prevention and treatment of ill health in England and Wales. One of NICE’s main roles is to produce national guidance on
Brazier, J.   +2 more
core   +3 more sources

Multi-agent utility theory for ethical conflict resolution

open access: yesJournal of Telecommunications and Information Technology, 2002
In this paper we try to construct a two-attribute group disutility function for two conflicting decision makers, taking into account the property of utility independence and/or convex dependence between them.
Hiroyuki Tamura
doaj   +1 more source

Home - About - Disclaimer - Privacy