Results 91 to 100 of about 555,141 (330)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Correction to: Multiple attribute group decision-making based on generalized aggregation operators under linguistic interval-valued Pythagorean fuzzy environment [PDF]

, 2021
Rajkumar Verma, Nikunj Agarwal
openalex   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Multi-test Decision Tree and its Application to Microarray Data Classification [PDF]

, 2014
Objective: The desirable property of tools used to investigate biological data is easy to understand models and predictive decisions. Decision trees are particularly promising in this regard due to their comprehensible nature that resembles the ...
Armstrong, Berzal, Breiman, Breiman, Breiman, Brodley, Brown, Brown, Che, Chen, Cohen, Cordell, Cowell, Czajkowski, Demsar, Dettling, Diaz-Uriarte, Dramiński, Fayyad, Freund, Freund, Ge, Golub, Grześ, Hall, Hastie, Hu, Kuo, Li, Marcin Czajkowski, Marek Grześ, Marek Kretowski, Murthy, Murthy, Pagallo, Qu, Quinlan, Robnik-Siikonja, Rokach, Rokach, Sebastiani, Shalev-Shwartz, Shi, Tan, Tan, Wold, Yeoh   +46 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

In the attraction, compromise, and similarity effects, alternatives are repeatedly compared in pairs on single dimensions [PDF]

, 2008
In multi-alternative choice, the attraction, compromise, and similarity effects demonstrate that the value of an alternative is not independent of the other alternatives in the choice-set.
Carr, AJ, Gwilym, SE, Pollard, TC
core   +1 more source

Some Novel Maclaurin Symmetric Mean Operators For q-Rung Picture Fuzzy Numbers and Their Application to Multiple Attribute Group Decision Making [PDF]

, 2023
Min Feng, Hongjun Guan
openalex   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Linguistic Intuitionistic Fuzzy Hamy Mean Operators and Their Application to Multiple-Attribute Group Decision Making

IEEE Access, 2019
The Hamy Mean (HM) operator is a useful aggregation tool characterized by considering the correlation between multiple integral parameters. The linguistic intuitionistic fuzzy numbers (LIFNs) use linguistic variables (LVs) to represent membership degree (
Peide Liu, Xiaoxiao Liu
doaj   +1 more source