Results 111 to 120 of about 174,325,441 (284)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Trends in socioeconomic inequalities in cause-specific premature mortality in Belgium, 1998–2019

BMC Public Health
Background Higher levels of socioeconomic deprivation have been consistently associated with increased risk of premature mortality, but a detailed analysis by causes of death is lacking in Belgium.
Martina Otavova, Bruno Masquelier, Christel Faes, Laura van den Borre, Bram Vandeninden, Eva de Clercq, Brecht Devleesschauwer   +6 more
doaj   +1 more source

Veneto Region dementia-related mortality during the COVID-19 pandemic: multiple causes of death and time series analysis. [PDF]

Eur J Public Health, 2023
Basso C, Barbiellini Amidei C, Casotto V, Schievano E, Dotto M, Tiozzo Netti S, Zorzi M, Fedeli U.   +7 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Analysis of the Underlying and Multiple Causes of Death for the Kuwaiti Population 40 years or over; Part II: Causes

Journal of High Institute of Public Health, 2009
Background: Death rarely results from a single cause; it can be caused by a variety of factors. Multiple causes of death (MCD) can provide information about the associations between causes of death revealing common combinations of conditions.
Kamel Alsaleh, Mesa Al-Saleh, Saadoun Al-Azmi, Zahra Al-Moweel, Bader Alnashi   +4 more
doaj   +1 more source

Four Decades of COPD Mortality Trends: Analysis of Trends and Multiple Causes of Death. [PDF]

J Clin Med, 2021
Fernández-García A, Pérez-Ríos M, Fernández-Villar A, Naveira G, Candal-Pedreira C, Santiago-Pérez MI, Represas-Represas C, Malvar-Pintos A, Cerdeira-Caramés S, Ruano-Raviña A.   +9 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Underlying and contributing causes of mortality from CDC WONDER—Insights for researchers

American Heart Journal Plus
Background: The multiple cause of death files available through the Center for Disease Control and Prevention Wide-ranging Online Data for Epidemiologic Research (CDC WONDER) present underlying and contributing causes of mortality.
Abdul Mannan Khan Minhas, Laurence S. Sperling, Sadeer Al-Kindi, Dmitry Abramov   +3 more
doaj   +1 more source

Sensitivity and Specificity of the National Death Index for Multiple Causes of Death in People With HIV. [PDF]

Public Health Rep, 2021
Schwarcz S, Hessol NA, Spinelli MA, Hsu LC, Wlodarczyk D, Tulsky J, Newman MD, Buchbinder SP.   +7 more
europepmc   +1 more source

Analysis of associations between multiple causes of death using methods of network analysis

, 2022
The aim of the thesis is the application of network analysis methods in the study of relationships between multiple causes of death. As a result of increasing life expectancy and of the growing proportion of people dying from chronic diseases in ...
Ukolova, Elizaveta
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