Results 101 to 110 of about 174,325,441 (284)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Deaths Mentioning Both Pancreatic Cancer and Renal Failure in the United States, 1999–2024: Temporal Trends and Disparities

Epidemiologia
Background: We examined temporal trends in deaths mentioning both pancreatic cancer and renal failure in the United States. Methods: We analyzed CDC WONDER multiple-cause-of-death data for adults aged ≥25 years from 1999 to 2024.
Arkadeep Dhali, Ali Shan Hafeez, Jyotirmoy Biswas, Ashish Sharma, Dushyant Singh Dahiya, Rick Maity, Saikat Mandal   +6 more
doaj   +1 more source

Causes of death, Australia, 2014

, 2016
Provides an insight into the diseases and factors contributing to life expectancy, potentially avoidable deaths, years of life lost and leading causes of death.
Australian Bureau of Statistics
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Death causes in breast cancer patients

, 2012
Background: Due to improved outcomes in breast cancer (BCa), the proportion of affected women dying of other causes has increased. Thus, a better survival of BCa requires knowledge of other causes of death.
Thomsen, H., Hemminki, Kari,, Riihimaeki, M., Sundquist, Jan,, Lund University., Brandt, A.   +5 more
core   +2 more sources

Physicians' pocket reference to the international list of causes of death.

, 1916
At head of title: ...Department of Commerce. Bureau of the Census. Sam L. Rogers, director.Pocket insert of: Manual of the international list of causes of death / United States. Bureau of the Census. Washington : Govt. Print.
United States. Bureau of the Census., Lappin, Richard C.   +1 more
core  

Global, regional, and national age-sex specific mortality for 264 causes of death, 1980-2016 [Elektronisk resurs] : a systematic analysis for the Global Burden of Disease Study 2016

, 2017
BACKGROUND: Monitoring levels and trends in premature mortality is crucial to understanding how societies can address prominent sources of early death.
GBD 2016 Causes of Death Collaborators, Lund University.   +1 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

[Multiple causes of death in Asturias, 1988].

Gaceta sanitaria, 1993
To analyse the frequency of the cause of death in the mortality statistical Bulletin, a study of a representative sample of the 1988 mortality statistical Bulletin (n = 595) of Asturias was conducted. The mean and the mode of the number of causes and also the complexity and density according to age and sex was analyzed.
A, García Tardón, J, Zaplana Piñeiro, R, Hernández Mejías, A, Cueto Espinar   +3 more
openaire   +1 more source