Results 91 to 100 of about 736,185 (247)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Trends in socioeconomic inequalities in cause-specific premature mortality in Belgium, 1998–2019

BMC Public Health
Background Higher levels of socioeconomic deprivation have been consistently associated with increased risk of premature mortality, but a detailed analysis by causes of death is lacking in Belgium.
Martina Otavova, Bruno Masquelier, Christel Faes, Laura van den Borre, Bram Vandeninden, Eva de Clercq, Brecht Devleesschauwer   +6 more
doaj   +1 more source

Analysis of the Underlying and Multiple Causes of Death for the Kuwaiti Population 40 years or over; Part II: Causes

Journal of High Institute of Public Health, 2009
Background: Death rarely results from a single cause; it can be caused by a variety of factors. Multiple causes of death (MCD) can provide information about the associations between causes of death revealing common combinations of conditions.
Kamel Alsaleh, Mesa Al-Saleh, Saadoun Al-Azmi, Zahra Al-Moweel, Bader Alnashi   +4 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Underlying and contributing causes of mortality from CDC WONDER—Insights for researchers

American Heart Journal Plus
Background: The multiple cause of death files available through the Center for Disease Control and Prevention Wide-ranging Online Data for Epidemiologic Research (CDC WONDER) present underlying and contributing causes of mortality.
Abdul Mannan Khan Minhas, Laurence S. Sperling, Sadeer Al-Kindi, Dmitry Abramov   +3 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Analysis of the Underlying and Multiple Causes of Death for the Kuwaiti Population 40 years and Over in Kuwait; Part I: Demographics

Journal of High Institute of Public Health, 2009
Background: Improved health care brought about major changes in mortality pattern; life expectancy has increased and the causes of death are more likely to result from chronic diseases, death rarely result from a single cause and the use of the ...
Kamel A. Alsaleh, Mesa Al-Saleh, Saadoun Al-Azmi, Ibtesam Alfares, Bader Alnashi, Fahad Al-Agmy   +5 more
doaj   +1 more source

Veneto Region dementia-related mortality during the COVID-19 pandemic: multiple causes of death and time series analysis. [PDF]

Eur J Public Health, 2023
Basso C, Barbiellini Amidei C, Casotto V, Schievano E, Dotto M, Tiozzo Netti S, Zorzi M, Fedeli U.   +7 more
europepmc   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Redistribution of heart failure deaths using two methods: linkage of hospital records with death certificate data and multiple causes of death data

Cadernos de Saúde Pública
Heart failure is considered a garbage code when assigned as the underlying cause of death. Reassigning garbage codes to plausible causes reduces bias and increases comparability of mortality data. Two redistribution methods were applied to Brazilian data,
Ana Luiza Bierrenbach, Gizelton Pereira Alencar, Cátia Martinez, Maria de Fátima Marinho de Souza, Gabriela Moreira Policena, Elisabeth Barboza França   +5 more
doaj   +1 more source