Results 81 to 90 of about 1,787,467 (299)

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

RELIABILITY OF THE DATA ON MORBIDITY AND MORTALITY FROM MUSCULOSKELETAL SYSTEM DISEASES IN RESIDENTS OF THE TULA REGION

Научно-практическая ревматология, 2014
Diseases of the musculoskeletal system (DMSS) are a topical social, medical, and economic problem. They are widespread and account for about 10% of the overall morbidity and primary disability of population, about 5% of primary morbidity, and about 0.1 ...
David Sh Vaisman, V N Sorotskaya, Roland M Balabanova   +2 more
doaj   +1 more source

A Theory of Health Investment under Competing Mortality Risks [PDF]

, 2002
In this paper we present a theory of health investment when there are multiple causes of death. Since there are several risks competing for one's life, the health investments in avoiding different causes of death are not independent in general.
Chang, Fwu-Ranq
core  

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Drug induced mortality: a multiple cause approach on Italian causes of death Register

Epidemiology, Biostatistics and Public Health, 2022
Background: Drug-related mortality is a complex phenomenon that has several health, social and economic effects. In this paper trends of drug-induced mortality in Italy are analysed.
Francesco Grippo, Marilena Pappagallo, Alessandra Burgio, Roberta Crialesi   +3 more
doaj  

Morbidity burden and community-based palliative care are associated with rates of hospital use by people with schizophrenia in the last year of life: A population-based matched cohort study [PDF]

, 2018
Objective: People with schizophrenia face an increased risk of premature death from chronic diseases and injury. This study describes the trajectory of acute care health service use in the last year of life for people with schizophrenia and how this ...
Arendts, Glenn, Brameld, Kate, Kelly, Brian, Rosenwax, Lorna, Spilsbury, Katrina   +4 more
core   +5 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Infecção hospitalar e causas múltiplas de morte Nosocomial infection and multiple causes of death

Jornal de Pediatria, 2002
Objetivo: este estudo se propôs a avaliar a possibilidade de se obter informações de infecção hospitalar por meio da declaração de óbito. Material e métodos: foi feita revisão de prontuários de crianças que faleceram com mais de 48 horas de internação ...
Ruth N.T. Turrini, Augusto H. Santo
doaj   +1 more source

Revisiting the mortality of France and Italy with the multiple-cause-of-death approach [PDF]

In this paper, we use the multiple cause-of-death approach to compare the mortality profiles of France and Italy in 2003. Our analysis leads to a substantial re-evaluation of the role played by certain conditions in the process leading to death ...
Aline Desesquelles, France Meslé, Luisa Frova, Marilena Pappagallo, Michele Antonio Salvatore, Monica Pace, Viviana Egidi   +6 more
core  

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source