Results 181 to 190 of about 7,829 (235)

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Planar Solid‐State Nanopores Toward Scalable Nanofluidic Integration Based on CMOS Technology

Advanced Engineering Materials, EarlyView.
We present a scalable silicon‐based fabrication strategy for planar solid‐state nanopores to enable their integration with complex nanofluidic systems. Prototype devices demonstrate normal voltage‐current characteristics, good noise performance, and appreciable streaming currents. Our CMOS‐compatible fabrication process offers precise geometric control
Ngan Hoang Pham, Chenyu Wen, Mohammad Hadi Khaksaran, Won‐Yong Lee, Javier Cruz, Klas Hjort, Dongping Wu, Shi‐Li Zhang   +7 more
wiley   +1 more source

Investigation of Laser Ablation and Brush Pre‐Treatments for AlCu Cold Roll Bonding in Oxygen‐Free Conditions

Advanced Engineering Materials, EarlyView.
It is shown that laser ablation pretreatment under oxygen‐free conditions enables copper–aluminium bonding at significantly lower deformation degrees and improved properties compared to mechanical brushing. Laser ablation further increases interface contact area and induces favourable residual stress states and microstructural compatibility ...
Khemais Barienti, Finn‐Lennard Janthur, Selina Raumel, Sascha Jan Zimmermann, Sarah Seffer, René Gustus, Sebastian Herbst, Marc C. Wurz, Ludger Overmeyer, Wolfgang Maus‐Friedrichs, Hans Jürgen Maier, Florian Nürnberger   +11 more
wiley   +1 more source

Immunological Issues in "Multiple Chemical Sensitivities"

Regulatory Toxicology and Pharmacology, 1993
openaire   +2 more sources

Microstructural Evolution and Vacancy Defect Formation in Mn–Mo–Ni RPV Steel Under Low Cycle Fatigue: Insights From EBSD and PALS

Advanced Engineering Materials, EarlyView.
Low‐cycle fatigue damage in Mn–Mo–Ni reactor pressure vessel steel is examined using a combined electron backscatter diffraction and positron annihilation lifetime spectroscopy approach. The study correlates texture evolution, dislocation substructure development, and vacancy‐type defect formation across uniform, necked, and fracture regions, providing
Apu Sarkar, Dhanadeep Dutta, G. Bharat Reddy   +2 more
wiley   +1 more source

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Noise Sensitivity and Multiple Chemical Sensitivity

Noise & Vibration Worldwide, 2013
Noise sensitivity is a personality trait covering attitudes to noise in general. Multiple chemical sensitivity (MCS) is the most commonly used label for clinical chemical intolerance. This study aimed to investigate if the Weinstein's Noise Sensitivity Scale and Quick Environmental Exposure and Sensitivity Inventory's (QEESI) Chemical Intolerance ...
Vuorinen Heikki S, Mussalo-Rauhamaa Helena, Kaprio Jaakko, Heikkilä Kauko Veli, Heinonen-Guzejev Marja, Koskenvuo Markku, Vuorinen Heikki S, Mussalo-Rauhamaa Helena, Kaprio Jaakko, Heikkilä Kauko Veli, Heinonen-Guzejev Marja, Koskenvuo Markku   +11 more
openaire   +1 more source

Multiple chemical sensitivities: review

Current Opinion in Otolaryngology & Head and Neck Surgery, 2007
There have been a number of recent studies examining behavioural and social factors in the potential cause of Multiple Chemical Sensitivities, or Idiopathic Environmental Intolerance. The current review will draw together recent research and suggest directions for future investigation.Recent studies have implicated a number of different perspectives ...
Das-Munshi, Jayati, Rubin, James, Wessely, Simon   +2 more
openaire   +3 more sources

Multiple chemical sensitivity: On the scent of central sensitization

International Journal of Hygiene and Environmental Health, 2013
Multiple Chemical Sensitivity (MCS) is a chronic condition characterized by recurrent, non-specific symptoms in response to chemically unrelated exposures in non-toxic concentrations. Although the pathophysiology of MCS remains unknown, central sensitization may be an important factor contributing to the clinical manifestations.To use quantitative ...
Tran, Marie Thi Dao, Arendt-Nielsen, Lars, Kupers, Ron, Elberling, Jesper   +3 more
openaire   +4 more sources

Multiple Chemical Sensitivities

Journal of Allergy and Clinical Immunology, 1993
In 1987 Cullen’ proposed the term multiple chemical sensitivities to define a condition that he described as “An acquired disorder characterized by recurrent symptoms, referable to multiple organ systems, occurring in response to demonstrable exposure to chemically unrelated compounds at doses far below those established in the general population to ...
openaire   +2 more sources

Mechanisms of multiple chemical sensitivity

Toxicology Letters, 2002
Sensitivity to chemicals is a toxicological concept, contained in the dose-response relationship. Sensitivity also includes the concept of hypersensitivity, although controversy surrounds the nature of effects from very low exposures. The term multiple chemical sensitivity has been used to describe individuals with a debilitating, multi-organ ...
openaire   +2 more sources