Results 41 to 50 of about 7,829 (235)

The use of a formal sensitivity analysis on epidemic models with immune protection from maternally acquired antibodies [PDF]

, 2011
This paper considers the outcome of a formal sensitivity analysis on a series of epidemic model structures developed to study the population level effects of maternal antibodies.
Chapman, James D., Chappell, M. J. (Michael J.), Evans, Neil D.   +2 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Nurturing the Ecosoma. Immune System and Impersonal (Dis)Cognition [PDF]

Phainomena
The article reexamines the immune system as a cognitive entity within an enactivism framework and the 4EA approach, emphasizing embodied, embedded, extended, enactive, and affective cognition.
Maxim D. Miroshnichenko
doaj   +1 more source

Inflammatory Mediator Profiling of n-butanol Exposed Upper Airways in Individuals with Multiple Chemical Sensitivity. [PDF]

PLoS ONE, 2015
Multiple Chemical Sensitivity (MCS) is a chronic condition characterized by reports of recurrent symptoms in response to low level exposure to various chemical substances.
Thomas Meinertz Dantoft, Sine Skovbjerg, Linus Andersson, Anna-Sara Claeson, Nina Lind, Steven Nordin, Susanne Brix   +6 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Clinical Diagnosis of the Dampness and Mold Hypersensitivity Syndrome: Review of the Literature and Suggested Diagnostic Criteria

Frontiers in Immunology, 2017
A great variety of non-specific symptoms may occur in patients living or working in moisture-damaged buildings. In the beginning, these symptoms are usually reversible, mild, and present irritation of mucosa and increased morbidity due to respiratory ...
Ville Valtonen
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

An Unusual Case of Multiple Food Allergies Comorbid with Multiple Chemical Sensitivity: A Case Report

Journal of Asthma and Allergy, 2021
Veronica Storino,1 Juliana Muñoz-Ortiz,2 Valeria Villabona-Martinez,3 Juan Diego Villamizar-Sanjuán,3 William Rojas-Carabali,3 Alejandra de-la-Torre3 1Faculty of Medicine, Universidad de los Andes, Bogotá, Colombia; 2Escuela ...
Storino V, Muñoz-Ortiz J, Villabona-Martinez V, Villamizar-Sanjuán JD, Rojas-Carabali W, de-la-Torre A   +5 more
doaj  

Indoor Air Quality and Health in Newly Constructed Apartments in Developing Countries: A Case Study of Surabaya, Indonesia

Atmosphere, 2019
In times of rapid urbanization, increasing usage of chemicals in buildings, and energy saving measures, the topic of indoor air quality (IAQ) demands reinforced attention. Nevertheless, especially in developing countries with urgent building construction
Sophia Hildebrandt, Tetsu Kubota, Hanief Ariefman Sani, Usep Surahman   +3 more
doaj   +1 more source