Results 61 to 70 of about 471,908 (230)

Prevalence and effects of multiple chemical sensitivities in Australia

Preventive Medicine Reports, 2018
Multiple chemical sensitivities (MCS) is a medical condition associated with exposure to common chemical pollutants. The aims of this study are to assess the prevalence of MCS, its overlaps with asthma and fragrance sensitivity, and its health and ...
Anne Steinemann
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Sensibilidad Química Múltiple: análisis de un caso registrado en un Hospital de referencia

Medicina y Seguridad del Trabajo
Resumen Introducción: La contaminación y la exposición a productos químicos han condicionado un aumento de la prevalencia de enfermedades crónicas no sólo explicables por la genética o susceptibilidad individual.
Mª Luisa Paredes Rizo
doaj  

Enhancing parental awareness on multiple chemical sensitivities: lessons from repeated cross-sectional questionnaire surveys on children

BMC Public Health
Background Multiple chemical sensitivity (MCS) is not yet familiar to the public. Patients suffer from a lack of understanding of their rare condition by those around them.
Akihiro Kawase, Masato Nagayoshi
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Chemical intolerance: involvement of brain function and networks after exposure to extrinsic stimuli perceived as hazardous

Environmental Health and Preventive Medicine, 2019
Background Chemical intolerance (CI) is a chronic condition characterized by recurring and severe symptoms triggered by exposure to low levels of odorous or pungent substances. The etiology of CI has been a controversial subject for a long time.
Kenichi Azuma, Iwao Uchiyama, Mari Tanigawa, Ikuko Bamba, Michiyo Azuma, Hirohisa Takano, Toshikazu Yoshikawa, Kou Sakabe   +7 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

A case of severe multiple chemical sensitivity (MCS): Proposed therapeutic strategies for MCS

Journal of Hospital General Medicine
Multiple chemical sensitivity (MCS) is hypothesized to involve chemically induced oxidative stress, systemic inflammation including hypercytokinemia, and resultant cellular dysfunction.
Shoji Kubo
doaj   +1 more source