Results 91 to 100 of about 1,773,114 (300)

A statistical approach to rank multiple priorities in Environmental Epidemiology: an example from high-risk areas in Sardinia, Italy

Geospatial Health, 2008
In Environmental Epidemiology, long lists of relative risk estimates from exposed populations are compared to a reference to scrutinize the dataset for extremes.
Dolores Catelan, Annibale Biggeri
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Statistics Corner: PostHoc Tests [PDF]

Journal of Postgraduate Medicine, Education and Research
Most researchers apply post hoc tests to pairwise compare groups after finding significant differences between groups using analysis of variance (ANOVA).
Kamal Kishore, Vidushi Jaswal, Tejinder Singh   +2 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Bayesian Hierarchical Poisson Models for Multiple Grouped Outcomes and Clustering with Applications to Observational Health Data

Journal of Open Research Software
Many populations or datasets contain structured data where relationships exist between the different variables. Bayesian hierarchical models may provide an appropriate approach for analysing this type of data, particularly if it accumulates over time ...
Raymond Carragher, Tanja Mueller, Marion Bennie, Chris Robertson   +3 more
doaj   +1 more source

Multiple comparisons of several homoscedastic multivariate populations

, 2009
Multiple comparisons, Bonferroni-type inequality, Maximum of correlated Hotelling’s T 2 statistics, Multivariate central nonsingular or singular chi-square distribution,
Yoshihide Kakizawa
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Significant subgraph mining for neural network inference with multiple comparisons correction. [PDF]

Netw Neurosci, 2023
Gutknecht AJ, Wibral M.
europepmc   +1 more source