Results 41 to 50 of about 50,764 (304)

Multiple Gastrointestinal Complications of Crack Cocaine Abuse [PDF]

open access: yesCase Reports in Medicine, 2014
Cocaine and its alkaloid free base “crack-cocaine” have long since been substances of abuse. Drug abuse of cocaine via oral, inhalation, intravenous, and intranasal intake has famously been associated with a number of medical complications. Intestinal ischemia and perforation remain the most common manifestations of cocaine associated gastrointestinal ...
Neal Carlin   +2 more
openaire   +3 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Dynamic response of multiple coplanar interface cracks between two dissimilar piezoelectric materials [PDF]

open access: yes, 2004
The linear piezoelectricity theory is applied to investigate the dynamic response of coplanar interface cracks between two dissimilar piezoelectric materials subjected to the mechanical and electrical impacts.
Feng, WJ, Zou, ZZ, Su, RKL
core  

Efficient solution of multiple cracks in great number using eigen COD boundary integral equations with iteration procedure

open access: yes, 2012
A newly developed computational approach is proposed in the paper for the analysis of multiple crack problems based on the eigen crack opening displacement (COD) boundary integral equations.
Yan, Cheng   +4 more
core   +1 more source

Interactions of Penny-Shaped Cracks in Three-Dimensional Solids [PDF]

open access: yes, 2006
The interaction of arbitrarily distributed penny-shaped cracks in three-dimensional solids is analyzed in this paper. Using oblate spheroidal coordinates and displacement functions, an analytic method is developed in which the opening and the sliding ...
Wang, TC (reprint author), Chinese Acad Sci, Inst Mech, LNM, Beijing 100080, Peoples R China.   +2 more
core   +1 more source

Automated Transverse Crack Mapping System with Optical Sensors and Big Data Analytics

open access: yesSensors, 2020
Transverse cracks on bridge decks provide the path for chloride penetration and are the major reason for deck deterioration. For such reasons, collecting information related to the crack widths and spacing of transverse cracks are important.
Kwanghee Won, Chungwook Sim
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Finite Element Analysis of Interface Cracks Using Multiple Point Constraints

open access: yes, 2010
A finite element technique to analyse closed-mode interface cracks is proposed in this study. Stress boundary conditions for a closed-tip model are transformed into multiple point constraints (MPCs) for nodal displacements.
劉昭華; Liu, Chao-hwa; Lin, Jui-hsiang
core   +1 more source

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