Results 51 to 60 of about 44,921 (261)

Interaction Analysis of Non-aligned Cracks Using Extended Finite Element Method

open access: yesLatin American Journal of Solids and Structures
Multiple flaws are frequently occurred in actual components, such as pressure vessels and power plants. These flaws will in some circumstances lead to more severe effects than single flaw alone.
Ali Abbaszadeh Bidokhti   +1 more
doaj   +1 more source

Change in mode shape nodes of multiple cracked bar: I. The theoretical study

open access: yesVietnam Journal of Mechanics, 2013
In present paper change in position of mode shape nodes induced by multiple cracks in bar is studied with purpose to use for the multiple crack detection from measured mode shape nodes. First, there is derived an explicit expression for natural modes in
Nguyen Tien Khiem   +2 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Numerical validation of burst pressure estimation equations for steam generator tubes with multiple axial surface cracks

open access: yesNuclear Engineering and Technology, 2019
This paper provides further validation of the burst pressure estimation equations for multiple axial surface cracked steam generator tubes, recently proposed by the authors based on analytical local collapse load approach against systematic FE damage ...
Ji-Seok Kim   +3 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Experimental Investigation on Crack Development Characteristics in Shallow Coal Seam Mining in China

open access: yesEnergies, 2019
The development of cracks in mining is the scientific basis for the safety and environmental exploitation of shallow multiple-seam. According to the “thickness of coal seam, interactive distance, and buried depth,„ four mining coal mines are ...
Qingxiang Huang, Yanpeng He, Jian Cao
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

A Crack Growth Evaluation Method for Interacting Multiple Cracks

open access: yesJSME International Journal Series A, 2003
When stress corrosion cracking or corrosion fatigue occurs, multiple cracks are frequently initiated in the same area. According to section XI of the ASME Boiler and Pressure Vessel Code, multiple cracks are considered as a single combined crack in crack growth analysis, if the specified conditions are satisfied.
openaire   +2 more sources

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

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