Results 71 to 80 of about 50,764 (304)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Experimental Investigation on Crack Development Characteristics in Shallow Coal Seam Mining in China

Energies, 2019
The development of cracks in mining is the scientific basis for the safety and environmental exploitation of shallow multiple-seam. According to the “thickness of coal seam, interactive distance, and buried depth,„ four mining coal mines are ...
Qingxiang Huang, Yanpeng He, Jian Cao
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

An analysis of the interaction between surface and basal crevasses in ice shelves [PDF]

The Cryosphere
The prescription of a simple and robust parameterization for calving is one of the most significant open problems in ice sheet modelling. One common approach to the modelling of crevasse propagation in calving in ice shelves is to view crevasse growth as
M. Zarrinderakht, C. Schoof, A. Peirce
doaj   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Fatigue properties and fracture mechanism of load carrying type fillet joints with one-sided welding

Fracture and Structural Integrity, 2015
The structures of the hydraulic excavator and the crane have numerous one-sided welded joints. However, attachments with box like structures are difficult to weld at both sides. Therefore, high accurate evaluation method is needed.
Takamasa Abe, Hiroyuki Akebono, Masahiko Kato, Atsushi Sugeta   +3 more
doaj   +2 more sources

Nonplanar Crack Growth Simulation of Multiple Cracks Using Finite Element Method

Advances in Materials Science and Engineering, 2020
This work deals with a 2D finite element simulation of nonplanar multiple cracks using fracture and crack propagation analysis. This analysis was performed by using the developed source code software written by Visual Fortran Language.
Yahya Ali Fageehi, Abdulnaser M. Alshoaibi   +1 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Vibration analysis of beam with multiple cracks [PDF]

, 2011
The present work deals with the free vibration analysis of a cracked beam with multiple transverse cracks using finite element method. In this analysis, an ‘overall additional flexibility matrix’, instead of the ‘local additional flexibility matrix’ is ...
Lakra, Sonam, Guria, Pradeep
core  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source