Results 81 to 90 of about 50,764 (304)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Study on the Effect of Cracking Parameters on the Migration Characteristics of Chloride Ions in Cracked Concrete

Buildings
In engineering, concrete often develops cracks due to various reasons, which accelerate the erosion rate of chloride ions in concrete and consequently expedite the degradation of the mechanical properties of concrete structures. This study simplifies the
Tao Huang, Shuang Feng, Mengge Wang, Zhongqi Peng   +3 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Numerical solution of stress intensity factors of multiple cracks in great number with eigen COD boundary integral equations

, 2013
Based on the eigen crack opening displacement (COD) boundary integral equations, a newly developed computational approach is proposed for the analysis of multiple crack problems.
Dhanasekar, M., Yan, C., Guo, Z., Ma, H.
core  

Burst pressure prediction of multiple cracks in pipelines [PDF]

, 2013
Available industrial code such as ASME B1G, modified ASME B1G and DNV RP- F101 to assess pipeline defects appear more conservative for multiple crack like- defects than single crack-like defects.
Nasrul Azuan, Alang, M. A, Murad, Norhaida, Ab. Razak   +2 more
core  

Experimental and Numerical Study of Concrete Fracture Behavior with Multiple Cracks Based on the Meso-Model. [PDF]

Materials (Basel), 2023
Wang Z, Zhang W, Huang Y.
europepmc   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

A new adaptable multiple-crack detection algorithm in beam-like structures

Archives of Mechanics, 2013
In this article, a simple method for detecting, localizing and quantifying multiple cracks in beams using natural frequencies is presented. We model cracks as rotational springs and demonstrate a relationship among natural frequencies, crack locations ...
A. Ghadami, A. Maghsoodi, H.R. Mirdamadi
doaj   +1 more source

Damage Detection on a Beam with Multiple Cracks: A Simplified Method Based on Relative Frequency Shifts. [PDF]

Sensors (Basel), 2021
Gillich GR, Maia NMM, Wahab MA, Tufisi C, Korka ZI, Gillich N, Pop MV.   +6 more
europepmc   +1 more source