Results 91 to 100 of about 44,921 (261)

PANoptosis in the pathogenesis of myelodysplastic syndromes

open access: yesMolecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla   +4 more
wiley   +1 more source

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Regulation mechanism of slot length on directional fracturing behavior of specimens under expansive loading

open access: yesInternational Journal of Mining Science and Technology
Static cracking demolition agent (SCDA) is an environmentally friendly and cost-effective material with broad potential for building demolition and rock fracturing engineering.
Yu Wang   +7 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

open access: yesMolecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho   +2 more
wiley   +1 more source

Soil desiccation cracking triggered by surface defects: Insight and mechanism based on strain/displacement analysis using DIC

open access: yesJournal of Rock Mechanics and Geotechnical Engineering
Soil desiccation cracking is a prevalent natural phenomenon that poses significant geotechnical and geoenvironmental challenges. Cracks typically initiate at surface defects such as air bubbles, large aggregates, tiny pits, or uneven surfaces, where ...
Tao Wang   +5 more
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

open access: yesMolecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

Detection of road cracks with multiple images

open access: yes, 2010
Extraire les défauts de surface de la chaussée par traitement d'images est une tâche difficile et, dans la plupart des cas, une seule image (acquisition) est utilisée. Les difficultés liées à cette tâche sont : les changements d'illumination, les objets présents sur la route et tous les artéfacts dus à l'acquisition en dynamique. Dans cet article, nous
openaire   +1 more source

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