Results 91 to 100 of about 2,277,621 (308)

A Speedy Cardiovascular Diseases Classifier Using Multiple Criteria Decision Analysis

Sensors, 2015
Each year, some 30 percent of global deaths are caused by cardiovascular diseases. This figure is worsening due to both the increasing elderly population and severe shortages of medical personnel.
Wah Ching Lee, Faan Hei Hung, Kim Fung Tsang, Hoi Ching Tung, Wing Hong Lau, Veselin Rakocevic, Loi Lei Lai   +6 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Automatic Substitution of Prioritization Methods Preserving Information Integrity

Administrative Sciences
Companies face multi-criteria problems every day, such as prioritizing projects, investments, and suppliers. In this respect, the literature offers countless methods, some of which provide partial and flawed solutions.
Joao Batista Mendes, Renato Dourado Maia, Marcos Flávio Silveira Vasconcelos D’Angelo, Iara Sibele Silva, Petr Y. Ekel, Matheus Pereira Libório   +5 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Multiple-criteria decision analysis for integrated catchment management

, 2006
Implementation of Integrated Catchment Management (ICM) is hampered by the lack of a conceptual framework for explaining how landowners select farming systems for their properties.
M Herath (15888020), T Prato (13278840)
core  

A Multi–Criteria Approach for Selecting an Explanation from the Set of Counterfactuals Produced by an Ensemble of Explainers

International Journal of Applied Mathematics and Computer Science
Counterfactuals are widely used to explain ML model predictions by providing alternative scenarios for obtaining more desired predictions. They can be generated by a variety of methods that optimize various, sometimes conflicting, quality measures and ...
Stepka Ignacy, Lango Mateusz, Stefanowski Jerzy   +2 more
doaj   +1 more source

Foreign direct investment performance drivers at the country level: a robust compromise multi-criteria decision-making approach

Technological and Economic Development of Economy
This paper focuses on the performance drivers of Foreign Direct Investment (FDI) at the country level, exploring the socio-demographic specifics of donor and receiver countries.
Peter Wanke, Yong Tan, Jorge Antunes, Ali Emrouznejad   +3 more
doaj   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

New MCEQLS fuzzy AHP methodology for evaluating learning repositories: a tool for technological development of economy

Technological and Economic Development of Economy, 2016
The paper aims to present a new methodology to evaluate the quality of features and functionality of learning object repositories (LORs). The quality of features and functionality of LORs is analysed in terms of engaging LOR users and content producers ...
Eugenijus Kurilovas, Irina Vinogradova, Svetlana Kubilinskiene   +2 more
doaj   +1 more source