Results 121 to 130 of about 2,350,890 (295)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Supporting contaminated sites management with Multiple Criteria Decision Analysis: Demonstration of a regulation-consistent approach. [PDF]

J Clean Prod, 2021
Cinelli M, Gonzalez MA, Ford R, McKernan J, Corrente S, Kadziński M, Słowiński R.   +6 more
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Multiple Criteria Decision Analysis (MCDA) for evaluating cancer treatments in hospital-based health technology assessment: The Paraconsistent Value Framework. [PDF]

PLoS One, 2022
Campolina AG, Estevez-Diz MDP, Abe JM, de Soárez PC.   +3 more
europepmc   +1 more source

Portfolio optimization using a hybrid of fuzzy ANP, VIKOR and TOPSIS [PDF]

, 2012
One of the primary questions in asset management is to find good combinations of different assets and this has been an interesting area of research for over half a century.
Mohammad Bahrani Jahromi, Reza Raei
core  

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Budapest Bridges Benchmarking [PDF]

This paper is concerned with the comparison of different scaling methods which are applied to a complex bridge evaluation problem. It is shown that both tangible and intangible data and satisfaction of multiple criteria are essential to the success of ...
András Farkas, György Kadocsa
core  

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Optimizing Jatropha curcas bioenergy plantations in Pakistan: A geospatial suitability analysis using advanced spatial modeling

Trees, Forests and People
Bioenergy from energy plants, an alternative fuel, is projected to increasingly meet future worldwide energy demands as well as those of a developing nation like Pakistan. Jatropha curcas (JC) has been found to possess many desirable qualities, including
Faisal Khalid, Sami Ullah, Sangam Khalil, Adnan Yousaf, Muhammad Shafique, Muhammad Tayyab Khan, Fariha Rehman, Nauman Ahmad, Khalil Ur Rahman, Majid Hussain   +9 more
doaj   +1 more source

Development and Practical Application of a Multiple-Criteria Decision Analysis Framework on Respiratory Inhalers: Is It Always Useful in the MOH Malaysia Medicines Formulary Listing Context? [PDF]

MDM Policy Pract, 2021
Yong YV, Mahamad Dom SH, Ahmad Sa'ad N, Lajis R, Md Yusof FA, Abdul Rahaman JA.   +5 more
europepmc   +1 more source