Results 41 to 50 of about 377,294 (261)

Multiplicites of Dihedral Discriminants [PDF]

Mathematics of Computation, 1992
Given the discriminant dk of a quadratic field k, the number of cyclic relative extensions N\k of fixed odd prime degree p with dihedral absolute Galois group of order 2p , which share a common conductor /, is called the multiplicity of the dihedral discriminant d^ = f2^p~^d^ .
openaire   +1 more source

Infant Embryonal CNS Tumors: Molecular Insights and Treatment Considerations for Contemporary Pediatric Neuro‐Oncology

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Embryonal tumors comprise the majority of malignant central nervous system (CNS) neoplasms diagnosed in children under 3 years of age. Compared with their counterparts in older children, these tumors exhibit distinct molecular biology and a more aggressive clinical phenotype, while their management is complicated by the heightened ...
Sudarshawn Damodharan, Mariah Wright‐Nadkarni, Mohamed S. Abdelbaki, Girish Dhall   +3 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

“Best Before”: On Women, Ageism, and Mental Health

Mental Health
Introduction: Our world has changed over the last decades, and one of the dramatic changes has been the increase in human life expectancy. Due to important life-saving breakthroughs, the current life expectancy for the world in 2024 is 73.33 years; and ...
Danylova Tetiana, Ilchuk Serhii, Storozhuk Svіtlana, Poperechna Galyna, Hoian Ihor, Kryvda Nataliia, Matviienko Iryna   +6 more
doaj   +1 more source

Moderators of the association between discrimination and alcohol consumption: findings from a representative sample of Brazilian university students

Trends in Psychiatry and Psychotherapy, 2015
Introduction: Few studies about discrimination and patterns of alcohol consumption among youth populations have been conducted outside the United States addressing different types of discriminatory experiences, in addition to racially motivated events ...
Isabela Zeni Coelho, João Luiz Bastos, Roger Keller Celeste   +2 more
doaj   +1 more source

Validation of Computer-Adaptive Contrast Sensitivity as a Tool to Assess Visual Impairment in Multiple Sclerosis Patients

Frontiers in Neuroscience, 2021
BackgroundImpairment of visual function is one of the major symptoms of people with multiple sclerosis (pwMS). A multitude of disease effects including inflammation and neurodegeneration lead to structural impairment in the visual system.
Sina C. Rosenkranz, Sina C. Rosenkranz, Barbara Kaulen, Barbara Kaulen, Hanna G. Zimmermann, Hanna G. Zimmermann, Ava K. Bittner, Ava K. Bittner, Michael Dorr, Jan-Patrick Stellmann, Jan-Patrick Stellmann, Jan-Patrick Stellmann, Jan-Patrick Stellmann   +12 more
doaj   +1 more source

MULTIPLE DISCRIMINANT ANALYSIS IN SOIL SURVEY

Journal of Soil Science, 1974
Summary Multiple discriminant analysis can be used to distinguish to best advantage several multivariate, more or less polythetic, classes of soil. The method allows profiles to be allocated consistently and most appropriately to existing groups for which representatives have already been chosen.
Webster, R., Burrough, P. A.
openaire   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source