Results 51 to 60 of about 377,294 (261)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Adaptive learning method for multiple-object detection in manufacturing

Advances in Mechanical Engineering, 2015
In manufacturing, vision-based inspections are effective nondestructive methods for implementing object discrimination. To minimize inspection times, multiple-object discrimination must be implemented for one inspection image.
Tsun-Kuo Lin
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Refugees, Race, and Gender: The Multiple Discrimination against Refugee Women

Refuge, 2001
This paper examines the intersectionality of race and gender in refugee situations, and the multiple forms of discrimination experienced by refugee women.
Eileen Pittaway, Linda Bartolomei
doaj   +1 more source

Paddy Crop and Weed Discrimination: A Multiple Classifier System Approach

International Journal of Agronomy, 2020
Weeds are unwanted plants that grow among crops. These weeds can significantly reduce the yield and quality of the farm output. Unfortunately, site-specific weed management is not followed in most of the cases. That is, instead of treating a field with a
Radhika Kamath, Mamatha Balachandra, Srikanth Prabhu   +2 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

A Discriminative Technique for Multiple-Source Adaptation

, 2020
We present a new discriminative technique for the multiple-source adaptation, MSA, problem. Unlike previous work, which relies on density estimation for each source domain, our solution only requires conditional probabilities that can easily be accurately estimated from unlabeled data from the source domains.
Corinna Cortes, Mehryar Mohri, Ananda Theertha Suresh, Ningshan Zhang   +3 more
openaire   +3 more sources

Multiple-schedule interactions and discrimination [PDF]

Animal Learning & Behavior, 1981
Pigeons received variable-interval (VI) reinforcement for keypecking during randomized presentations of seven line-orientation stimuli forming a continuum ranging from horizontal (0 deg) to vertical (90 deg). Each line presentation lasted for 30 sec and was preceded and followed by 30-sec time-outs.
David W. Rowe, John C. Malone
openaire   +1 more source