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Molecular cytogenetics of multiple drug resistance
Cytotechnology, 1993The refractory nature of many human cancers to multi-agent chemotherapy is termed multidrug resistance (MDR). In the past several decades, a major focus of clinical and basic research has been to characterize the genetic and biochemical mechanisms mediating this phenomenon.
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Multiple Drug Resistance Mechanisms in Cancer
Molecular Biotechnology, 2010Multiple drug resistance (multidrug resistance; MDR), a phenomenon whereby human tumours that acquire resistance to one type of therapy are found to be resistant to several other drugs that are often quite different in both structure and mode of action, has been recognised clinically for several decades. An important advance in our understanding of MDR
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Multiple drug resistance in the pathogenic protozoa
Acta Tropica, 1994Evidence for the phenomenon of multiple drug resistance (MDR) in the well studied pathogenic protozoa has been examined. This has been placed in the more familiar context of the MDR efflux transporters and the cloned mdr genes of mammalian cells. Homologues of the mdr gene family in protozoa and their possible role in drug efflux have been compared ...
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Drug resistance in multiple myeloma.
Pathologie-biologie, 1999Multidrug resistance (MDR) is a pleiotropic resistance against several unrelated drugs. It may be induced by prolonged exposure of cells to drugs such as doxorubicin, etoposide and vinca alkaloids. Once MDR develops in clinical tumors, it is a major obstacle for the improvement of treatment of multiple myeloma (MM).
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[Multiple resistance to drugs by MRSA].
Nihon rinsho. Japanese journal of clinical medicine, 1992Most methicillin-resistant Staphylococcus aureus (MRSA) isolates are multiply resistant to various antimicrobial agents. Therefore, MRSA strains have become a serious problem in the clinical setting. However, it should be noted that the frequency of isolation of strains resistant to aminoglycoside and minocycline was not significantly different between
M, Inoue, N, Hasobe, Y, Hirata, T, Okubo
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Autophagy: A Potential Therapeutic Target to Tackle Drug Resistance in Multiple Myeloma
International Journal of Molecular Sciences, 2023Hossein Tabatabaeian +2 more
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Emerging Therapeutic Strategies to Overcome Drug Resistance in Multiple Myeloma
Cancers, 2021Lorraine Davis +2 more
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Targeting an MDM2/MYC Axis to Overcome Drug Resistance in Multiple Myeloma
Cancers, 2022Eldad Zacksenhaus +2 more
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Multiple Myeloma: Available Therapies and Causes of Drug Resistance
Cancers, 2020Hugo R Caires +2 more
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