Results 11 to 20 of about 23,289 (161)

Efficacy and safety of pralsetinib in multiple endocrine neoplasia type 2-associated pheochromocytoma: a case report [PDF]

Therapeutic Advances in Endocrinology and Metabolism
A 34-year-old male developed bilateral recurrent pheochromocytomas 10 years after laparoscopic adrenal-sparing surgery for pheochromocytomas. Based on his clinical manifestations and germline REarranged during Transfection (RET) variant, the patient was ...
Shiwei Chen, He Wang, Qi Shen, Wencong Han, Kun Peng, Tai Kang, Zejin Ou, Zheng Zhang   +7 more
doaj   +2 more sources

Multiple endocrine neoplasia 2: an overview

Therapeutic Advances in Chronic Disease, 2022
This review article discusses the diagnosis and treatment of patients with multiple endocrine neoplasia type 2 (MEN2). The most common tumors associated with MEN2 are those of the parathyroid, thyroid, and adrenal glands.
B Saravana-Bawan, JD Pasternak
doaj   +2 more sources

Germline BRCA1 Mutation Detected in a Multiple Endocrine Neoplasia Type 2 Case With RET Codon 634 Mutation [PDF]

Frontiers in Genetics, 2019
Coincidences of more than one pathogenic mutation in high and/or moderate risk-associated cancer genes have been rarely reported, and the implication for disease progression has been debated.
Balázs Sarkadi, Balázs Sarkadi, Kornélia Baghy, Kornélia Baghy, Zoltán Sápi, Gábor Nyirő, Gábor Nyirő, István Likó, István Likó, Attila Patócs, Attila Patócs   +10 more
doaj   +2 more sources

Patient‐Reported Outcomes with Selpercatinib Treatment Among Patients with RET‐Mutant Medullary Thyroid Cancer in the Phase I/II LIBRETTO‐001 Trial

The Oncologist, EarlyView., 2021
Abstract Background Medullary thyroid cancer (MTC) standard of care includes multikinase inhibitors (MKIs), which can exacerbate disease‐related diarrhea, primarily because of non‐RET kinase inhibition. We report diarrhea and other patient‐reported outcomes (PROs) with selpercatinib, a highly selective RET inhibitor, among patients with RET‐mutant MTC ...
Lori J. Wirth, Bruce Robinson, Valentina Boni, Daniel S.W. Tan, Caroline McCoach, Erminia Massarelli, Lisa M. Hess, Min‐Hua Jen, Jennifer Kherani, Elizabeth Olek, Vivek Subbiah   +10 more
wiley   +1 more source

Interdisciplinary data bank in oncoendocrinology. Medullary thyroid cancer and type 2 multiple endocrine neoplasia syndromes [PDF]

Эндокринная хирургия, 2020
Medullary thyroid cancer (MTC) is about 5% of all thyroid carcinomas and is hereditary in 2030% of cases. Multiple endocrine neoplasia syndrome type 2 (MEN2), in addition to medullary thyroid cancer, may include pheochromocytoma, hyperparathyroidism, and
Pavel O. Rumiantsev, Konstantin Y. Slashchuk, Sergey V. Korenev, Andrei G. Goncharov, Dmitriy G. Beltsevich, Olga S. Chukhacheva   +5 more
doaj   +1 more source

Multiple endocrine neoplasia type 2

Orphanet Journal of Rare Diseases, 2006
Multiple Endocrine Neoplasia Type 2 (MEN2) is a rare hereditary complex disorder characterized by the presence of medullary thyroid carcinoma (MTC), unilateral or bilateral pheochromocytoma (PHEO) and other hyperplasia and/or neoplasia of different ...
Luzi Ettore, Tognarini Isabella, Carbonell Sala Silvia, Del Monte Francesca, Falchetti Alberto, Marini Francesca, Brandi Maria   +6 more
doaj   +1 more source

Innovations in the systemic treatment of medullary thyroid cancer with kinase inhibitors

Journal of Education, Health and Sport, 2023
Introduction: Medullary thyroid carcinoma is a primary thyroid neoplasm originating from thyroid C cells. It can be familial or sporadic. The familial form is associated with multiple endocrine neoplasia (MEN) syndrome types 2A and 2B and is caused by a
Wiktoria Lipczyńska, Adam Jasiura, Hubert Kasprzak, Agata Justyńska, Hanna Krafzik, Konrad Warchoł, Przemysław Stępień, Sylwiusz Niedobylski   +7 more
doaj   +1 more source

Genotype-phenotype correlation in multiple endocrine neoplasia type 2

Clinics, 2012
Multiple endocrine neoplasia type 2 is an autosomal-dominant hereditary cancer syndrome caused by missense gain-of-function mutations of the rearranged during transfection proto-oncogene, which encodes the receptor tyrosine kinase, on chromosome 10.
Friedhelm Raue, Karin Frank-Raue
doaj   +1 more source

Metastatic thyroid cancer after thyroidectomy in patient with MEN2A syndrome: a case report

Liječnički vjesnik, 2023
Multiple Endocrine Neoplasia Type 2 (MEN 2) is a complex hereditary disorder with a genetic predisposition toward the development of endocrine tumors.
Ana Čala, Tina Dušek
doaj   +1 more source

A case report of non-syndromic colonic ganglioneuroma in a patient with juvenile polyposis. [PDF]

JPGN Rep
Abstract Colonic ganglioneuromas in children are rare, particularly without associated hereditary syndromes like multiple endocrine neoplasia (MEN2B), neurofibromatosis type 1(NF1), or Phosphatase and tensin homolog hamartoma tumor syndrome (PHTS). We report a 12‐year‐old male with a history of juvenile polyposis syndrome (JPS) and segmental colonic ...
Coffey H, Arora K, Giefer MJ.
europepmc   +2 more sources