Results 111 to 120 of about 681,106 (299)
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Design of ceramic components with the NASA/CARES computer program [PDF]
The ceramics analysis and reliability evaluation of structures (CARES) computer program is described. The primary function of the code is to calculate the fast-fracture reliability or failure probability of macro-scopically isotropic ceramic components ...
Gyekenyesi, John P. +2 more
core +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
EPJ Web of Conferences, 2018 Resistance Spot Welding (RSW) is widely used in the automotive industry thanks to its production convenience and cost effectiveness. Around four thousands spot welds are indeed employed to assemble the body-in-white.
Chtourou Rim +5 more
doaj +1 more source
Initiation and propagation mechanisms of progressive crushing in carbon-epoxy laminated plates [PDF]
, 2008 This article presents original experiments that enhance the understanding of the mechanisms that drive the progressive crushing of fiber-reinforced laminated composite materials and their energy absorption capability.
Barrau, Jean-Jacques +5 more
core
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
The effects of participatory mode and task workload on the detection of dynamic system failures [PDF]
The ability of operators to detect step changes in the dynamics of control systems is investigated as a joint function of, (1) participatory mode: whether subjects are actively controlling those dynamics or are monitoring an autopilot controlling them ...
Kessel, C., Wickens, C. D.
core +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Inherent Problems in Designing Two-Failure Tolerant Electromechanical Actuators [PDF]
, 1984 An electromechanical ac-powered rotary actuated four-bar linkage system for rotating the Shuttle/Centaur deployment adapter is described. The essential features of the deployment adapter rotation system (DARS) are increased reliability for mission ...
Hornyak, S.
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source