Results 121 to 130 of about 681,106 (299)

A Hybrid FMEA-ROC-CoCoSo Approach for Improved Risk Assessment and Reduced Complexity in Failure Mode Prioritization

Algorithms
This paper proposes a novel hybrid model that integrates failure mode and effects analysis (FMEA), Rank Order Centroid (ROC), and Combined Compromise Solution (CoCoSo) to improve risk assessment and prioritization of failure modes.
Vitor Anes, António Abreu
doaj   +1 more source

New Modes of Governance in Europe: Policy Making without Legislating? IHS Political Science Series: 2002, No. 81 [PDF]

, 2002
The article analyzes new modes of governance in Europe. Firstly, different types of new governance, the open coordination method and voluntary accords, and their individual elements are identified.
Héritier, Adrienne
core  

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Research on gear reliability based on improved fourth moment

Jixie qiangdu
Gear is the most commonly used transmission component, and its most common failure mode is tooth surface pitting and tooth root fracture. In order to analyze its reliability quickly and accurately, an improved fourth moment method considering failure ...
WANG ChunRong, ZHOU FuPing, XIA ErDong, GAO Hao   +3 more
doaj  

A novel reliability analysis methodology based on IPSO-MCopula model for gears with multiple failure modes

Advances in Mechanical Engineering
In order to accurately and quickly predict the failure probability of gears with multiple failure modes, a novel reliability analysis methodology based on the mixed Copula (MCopula) function model is proposed to deal with the complex correlation among ...
Xia ErDong, Zhou FuPing, Wang Kun-Chieh, Wang ChunRong, Gao Hao   +4 more
doaj   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Vibration based Structural Health Monitoring of a Composite Plate Structure with Multiple Stiffeners [PDF]

, 2010
A vibration based damage identification method is investigated experimentally.\ud The dynamic response of an intact and a locally damaged 16–layer unidirectional\ud carbon fibre PEKK reinforced plate structure with two stiffener sections is considered ...
Akkerman, R., Boer, A. de, Loendersloot, R., Ooijevaar, T.H., Warnet, L.L.   +4 more
core   +2 more sources

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Research and engineering application of layout optimization for lockbolt structures in railway wagons considering multidimensional failure modes based on MSNSGA-III

Scientific Reports
The lockbolt structure is essential in railway wagons, and a scientific lockbolt layout can ensure uniform load distribution, thereby preventing failure. However, current engineering lacks layout optimization methods that address multidimensional failure
Dailin Zhang, Xiaofeng Li, Qiang Zhang, Xinli Han, Shuai Wang, Qiaoyan Ma   +5 more
doaj   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source