Results 41 to 50 of about 681,106 (299)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Predictable Behavior of GFRP-Reinforced Bridge Decks: Formulation of a Strain-Based Capacity Model

International Journal of Polymer Science, 2019
This paper proposes a reliability analysis framework for glass fiber-reinforced polymer- (GFRP-) reinforced concrete systems with uncertain capacities and demands over time. Unfortunately, there has been limited discussion or research done related to the
Young Hoon Kim, Yeesock Kim, Yeonho Park
doaj   +1 more source

System reliability analysis of slopes based on weighted uniform simulation method

Yantu gongcheng xuebao, 2021
In practical engineering, due to the slope stratification or the spatial variability of soil properties, the slope will often fail along multiple potential sliding surfaces.
JI Jian 1, 2, WANG Le-pei 1, LIAO Wen-wang 1, ZHANG Wei-jie 1, 2, ZHU De-sheng 3, GAO Yu-feng 1, 2
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Safety verification of a fault tolerant reconfigurable autonomous goal-based robotic control system [PDF]

, 2007
Fault tolerance and safety verification of control systems are essential for the success of autonomous robotic systems. A control architecture called Mission Data System (MDS), developed at the Jet Propulsion Laboratory, takes a goal-based control ...
Braman, Julia M. B., Murray, Richard M., Wagner, David A.   +2 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Promoting sustainable water distribution networks: Modeling of water pipe failure factors and modes

Cleaner Engineering and Technology
Water pipe failure significantly undermines the sustainability and resilience of water distribution networks (WDNs), leading to substantial environmental, economic, and social impacts.
Ridwan Taiwo, Tarek Zayed, Nehal Elshaboury, Ghasan Alfalah, Eslam Mohammed Abdelkader   +4 more
doaj   +1 more source

Machine Hyperconsciousness [PDF]

, 2006
Individual animal consciousness appears limited to a single giant component of interacting cognitive modules, instantiating a shifting, highly tunable, Global Workspace.
Wallace, Rodrick
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source