Results 61 to 70 of about 676,606 (300)
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Reliability Measurements of the Furniture Frames with Selected Joint Types
BioResourcesThe reliability was evaluated for frame construction with mortise and tenon (MT), dowel, and non-glued and glued staple joints made of beech wood. The moment capacities of the T-shaped joints were determined under static vertical loads.
Mesut Uysal
doaj +2 more sources
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
RESEARCH ON MULTIPLE FAILURE MODES FOR RELIABILITY CALCULATION IN CRACK GROWTH LIFE BY SQP METHOD
Jixie qiangdu, 2019 The fatigue crack growth（FCG） phenomenon always exists in large mechanical structural. Influenced by varied kinds of random factors, the safety evaluation of structure in FCG is under great uncertainty.
SUN YuanTao +3 more
doaj
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Acoustic Emission Characteristics and Damage Evolution of Rock under Different Loading Modes
Energies, 2020 To study the evolution of acoustic emission (AE) parameters and the differences in the fracturing and failure process of rocks under different loading modes, AE signals of marble were detected during uniaxial compression tests (UCTs), direct tensile ...
Ersheng Zha +7 more
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Jixie qiangdu, 2019 In order to solve the problem of reliability sensitivity analysis of tracked vehicle transmission gears in the presence of different failure modes, the random perturbation theory, the fourth moment method and Edgeworth series are employed to calculate ...
YAN SiHong, TAO FengHe, JIA ChangZhi
doaj
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source