Results 61 to 70 of about 681,106 (299)

Semiparametric Estimates and Goodness-of-Fit Tests for Tire Wear and Failure Time Data

Nonlinear Analysis, 2002
The goodness-of-fit test for tire wear and failure time data with multiple failure modes is proposed. Parametric estimators of traumatic event cumulative intensities and semiparametric estimates of various reliability characteristics are given and their ...
Rūta Levulienė
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Compression of thick laminated composite beams with initial impact-like damage [PDF]

While the study of compression after impact of laminated composites has been under consideration for many years, the complexity of the damage initiated by low velocity impact has not lent itself to simple predictive models for compression strength.
Breivik, N. L., Griffin, O. H., Jr., Guerdal, Z.   +2 more
core   +1 more source

A Peer-to-Peer Middleware Framework for Resilient Persistent Programming [PDF]

, 2010
The persistent programming systems of the 1980s offered a programming model that integrated computation and long-term storage. In these systems, reliable applications could be engineered without requiring the programmer to write translation code to ...
Dearle, Alan, Kirby, Graham, McCarthy, Andrew, Norcross, Stuart   +3 more
core   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

RESEARCH ON MULTIPLE FAILURE MODES FOR RELIABILITY CALCULATION IN CRACK GROWTH LIFE BY SQP METHOD

Jixie qiangdu, 2019
The fatigue crack growth（FCG） phenomenon always exists in large mechanical structural. Influenced by varied kinds of random factors, the safety evaluation of structure in FCG is under great uncertainty.
SUN YuanTao, ZHANG ZengZeng, ZHANG Qing, QIN XianRong   +3 more
doaj  

Protective wrapping of off-the-shelf components [PDF]

, 2005
System designers using off-the-shelf components (OTSCs), whose internals they cannot change, often use add-on “wrappers” to adapt the OTSCs’ behaviour as required.
Jefferson, N., Riddle, S., Strigini, L., van der Meulen, M.   +3 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

An efficient hybrid reliability analysis method with application to the harmonic drive.

PLoS ONE
The harmonic drive is a new type of high-efficiency gear transmission system, widely used in precision machinery, robotics, and aerospace due to its compact structure and high transmission accuracy, and the multiple uncertain parameters in it will ...
Jingqi Cui, Di Zuo, Xiaoxi Men, Chongshuai Wang   +3 more
doaj   +1 more source

Step-path failure mechanism of rock slopes based on crack coalescence modes in rock mass

Yantu gongcheng xuebao, 2017
The crack propagation and coalescence mode play an important role in the step-path failure mechanism of rock slopes. By using the discrete element method (DEM), the coalescence modes between two pre-existing cracks with different geometries (rock bridge ...
ZHU Lei , HUANG Run-qiu , YAN Ming , CHEN Guo-qing
doaj   +1 more source