Results 71 to 80 of about 681,106 (299)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Jixie qiangdu, 2019 In order to solve the problem of reliability sensitivity analysis of tracked vehicle transmission gears in the presence of different failure modes, the random perturbation theory, the fourth moment method and Edgeworth series are employed to calculate ...
YAN SiHong, TAO FengHe, JIA ChangZhi
doaj
Safety Analysis of Storm Sewer Using Probability of Failure and Multiple Failure Mode
Journal of Korea Water Resources Association, 2010 AFDA (Approximate Full Distribution Approach) model of FORM (First-Order Reliability Model) which can quantitatively calculate the probability that storm sewer reach to performance limit state was developed in this study. It was defined as a failure if amount of inflow exceed the capacity of storm sewer.
Hyuk-Jae Kwon, Cheol-Eung Lee
openaire +2 more sources
Optimization of composite structures [PDF]
Structural optimization is introduced and examples which illustrate potential problems associated with optimized structures are presented. Optimized structures may have very low load carrying ability for an off design condition.
Stroud, W. J.
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
On energy mechanism of rate-dependent failure mode evolution in plain weave composite
Polymer TestingThe intricate failure modes and the yet unclear rate dependency of carbon fiber reinforced plain weave composite materials pose a challenge to mechanics researchers.
Yongshuai Wang +5 more
doaj +1 more source
Energies, 2014 This study presented a failure analysis of a 52.3 m composite wind turbine blade under static loading. Complex failure characteristics exhibited at the transition region of the blade were thoroughly examined and typical failure modes were indentified. In
Xiao Chen +3 more
doaj +1 more source
Active learning surrogate models for the conception of systems with multiple failure modes [PDF]
Reliability Engineering & System Safety, 2016 The conception (or risk assessment) of complex mechanical systems has to take into account a series of constraints. Such constraints can be due to certification criteria, performance objectives, cost limitations, and so on. In this context, the role of simulation has kept increasing for the last decades, as it should be able to predict if a given ...
openaire +3 more sources
Practical extensions to the level of repair analysis [PDF]
, 2010 The level of repair analysis (lora) gives answers to three questions that are posed when deciding on how to maintain capital goods: 1) which components to repair upon failure and which to discard, 2) at which locations in the repair network to perform ...
Basten, R.J.I. +2 more
core +3 more sources
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source