Results 51 to 60 of about 676,606 (300)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Predictable Behavior of GFRP-Reinforced Bridge Decks: Formulation of a Strain-Based Capacity Model

International Journal of Polymer Science, 2019
This paper proposes a reliability analysis framework for glass fiber-reinforced polymer- (GFRP-) reinforced concrete systems with uncertain capacities and demands over time. Unfortunately, there has been limited discussion or research done related to the
Young Hoon Kim, Yeesock Kim, Yeonho Park
doaj   +1 more source

Recognition and Analysis of Unexpected Modes of Modular Multilevel Converter

IEEE Access, 2021
The modular multilevel converter (MMC) with the clamp double submodule (CDSM) performs outstandingly on the handling of DC fault current. As CDSM is composed of multiple switching devices, different operating modes can be produced according to the ...
Xiaofu Fan, Dongyuan Qiu, Bo Zhang, Yanfeng Chen, Fan Xie, Changhai Yuan   +5 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Analysis of a Semi-Markov Cold Standby System with Two Heterogeneous Components Considering Multiple Failure Modes

Axioms
In this paper, a cold standby repairable system comprising two heterogeneous components, each characterized by multiple types of mutually independent failure modes, is investigated.
Ping Zhang, Jinsong Hu, Wenqing Wu
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Time-Variant Reliability Analysis via Copula Failure Correlation and Advanced Kriging

Mathematics
In practical engineering, mechanical structures are affected by time-dependent uncertainties and by correlated failure modes. This study proposes an enhanced time-variant reliability analysis framework by coupling a mixed Archimedean Copula model with an
Debiao Meng, Huaxi Wu, Muhammad Umar Khan, Juan Huang, Lu-Kai Song, Shiyuan Yang   +5 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A modelling approach to optimal imperfect maintenance of repairable equipment with multiple failure modes [PDF]

Computers & industrial engineering, 2019
Most of the existing works on optimal imperfect maintenance activities of a repairable equipment with independent components consider a single model for equipment behaviour.
R. Mullor, J. Mulero, M. Trottini
semanticscholar   +1 more source