Results 81 to 90 of about 676,606 (300)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Modular Approach for Probabilistic Safety Assessment of Systems with Multiple Failure Modes

IFAC-PapersOnLine, 2015
Probabilistic safety assessment (PSA) becomes quite difficult for the complex systems with different failure modes that are represented by Markov processes characterized by a large number of states and transitions. In order to overcome the complexity of this problem, we propose to build the Markov processes corresponding to each failure mode separately
Ionescu, Dorina Romina, Brinzei, Nicolae, Pétin, Jean-Francois   +2 more
openaire   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Time-Variant Reliability Analysis of Satellite Solar Panel Deployment Mechanism Under Multiple Failure Modes Using SILK Model

IEEE Access
The solar panel deployment mechanism is a critical subsystem for satellite power supply. Its operational reliability directly determines the success of satellite missions.
Ke Wang, Hongchen Qu
doaj   +1 more source

Failure Test and Finite Element Simulation of a Large Wind Turbine Composite Blade under Static Loading

Energies, 2014
This study presented a failure analysis of a 52.3 m composite wind turbine blade under static loading. Complex failure characteristics exhibited at the transition region of the blade were thoroughly examined and typical failure modes were indentified. In
Xiao Chen, Wei Zhao, Xiao Lu Zhao, Jian Zhong Xu   +3 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Research on Crowbar Protection Circuit in Traction Converter

机车电传动, 2021
In view of the current status of IGBT failures causing serious consequences in traction converter, several common IGBT power module failure modes were analyzed, crowbar protection circuit and principle were introduced, and the qualitative and ...
Yupeng LI, Jianhui FU, Yongjiang LIU, Ronghui FAN, Xionghui TANG, Zhenjun LIN   +5 more
doaj  

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

On energy mechanism of rate-dependent failure mode evolution in plain weave composite

Polymer Testing
The intricate failure modes and the yet unclear rate dependency of carbon fiber reinforced plain weave composite materials pose a challenge to mechanics researchers.
Yongshuai Wang, Qiong Deng, Lianyang Chen, Haodong Wang, Tao Suo, Cunxian Wang   +5 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source