Results 91 to 100 of about 948,028 (287)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

A Comprehensive Timing Analysis of Individual Pulses in X-Ray Bursts from SGR J0501+4516

The Astrophysical Journal Supplement Series
The pulses in X-ray-burst (XRB) light curves from soft gamma-ray repeaters (SGRs) are generally thought to arise from magnetic crustal fractures or magnetic reconnection, reflecting the evolution of the energy release process in magnetars. In this study,
Jiao-Jiao Yang, Shuo Xiao, Zheng-Huo Jiang, Tong-Lei Liao, Mei-Xin Hong, Xi-Hong Luo   +5 more
doaj   +1 more source

On the Special Functions Higher than the Multiple Gamma-Functions

Tokyo Journal of Mathematics, 2000
Barnes' multiple zeta function is defined by \[ \zeta_r(s;w;\omega_1,\cdots,\omega_r)= \sum_{m_1,\cdots,m_r=0}^\infty(w+m_1\omega_1+\cdots+m_r\omega_r)^{-s}. \] The author gives a formula representing \(\zeta_{r+1}''(0;w;\omega_1,\cdots,\omega_r,\omega_{r+1})\) by \(\zeta_r'' (0;w;\omega_1,\cdots,\omega_r)\) and Barnes' multiple Bernoulli polynomials ...
openaire   +3 more sources

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Long-Term Egg Production Curve Fitting Using Nonlinear Models For Superior Local Chicken of Indonesia [PDF]

Poultry Science Journal
The objective of this study was to analyze the unique tendencies reported along the egg-production curve for the Kampung Unggul Badan Litbang Pertanian (KUB) chicken.
Nurfaizin Nurfaizin, Fitri Astuti, Dwinta Prasetiyanti, Dwi wijayanti, Firda Kamila, Sugiharto Sugiharto, Asep Setiaji   +6 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Gamma Radiation-Induced Damage in the Zinc Finger of the Transcription Factor IIIA

Bioinorganic Chemistry and Applications, 2016
A zinc finger motif is an element of proteins that can specifically recognize and bind to DNA. Because they contain multiple cysteine residues, zinc finger motifs possess redox properties.
XiaoHong Zhang, YuJi Miao, XiaoDan Hu, Rui Min, PeiDang Liu, HaiQian Zhang   +5 more
doaj   +1 more source

Multiple p-adic log-gamma functions and their characterization theorem [PDF]

Acta Arithmetica, 2010
The author introduces multiple \(p\)-adic log-gamma functions defined on \(\mathbb C_p\setminus\mathbb Z_p\) for nonnegative integers, which are generalizations of Diamond's \(p\)-adic log--gamma function, and give properties characterizing them.
openaire   +2 more sources