Results 91 to 100 of about 682,858 (276)

Quantifying network properties in multi-electrode recordings: Spatiotemporal characterization and inter-trial variation of evoked gamma oscillations in mouse somatosensory cortex in vitro

Frontiers in Computational Neuroscience, 2013
Linking the structural connectivity of brain circuits to their cooperative dynamics and emergent functions is a central aim of neuroscience research. Graph theory has recently been applied to study the structure-function relationship of networks, where ...
Cristian eCarmeli, Paolo eBonifazi, Paolo eBonifazi, Hugh eRobinson, Michael eSmall   +4 more
doaj   +1 more source

Generalized Hölder's Theorem for Vignéras' Multiple Gamma Function

Tokyo Journal of Mathematics, 2001
The multiple gamma function is defined by \[ G_r(z+1)= G_{r-1}(z) G_r(z),\;G_r(1)=1,\;{d^{r+1} \over dz^{r+1}} \log G_r(z+1)\geq 0 \] for \(z\geq 0,\;G_0(z)=z.\) The gamma function is therefore \(\Gamma(z)= G_1(z)\). Hölder proved that the gamma function does not satisfy any algebraic differential equation over the rational field \(\mathbb{C}(z)\).
openaire   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

On the Special Functions Higher than the Multiple Gamma-Functions

Tokyo Journal of Mathematics, 2000
Barnes' multiple zeta function is defined by \[ \zeta_r(s;w;\omega_1,\cdots,\omega_r)= \sum_{m_1,\cdots,m_r=0}^\infty(w+m_1\omega_1+\cdots+m_r\omega_r)^{-s}. \] The author gives a formula representing \(\zeta_{r+1}''(0;w;\omega_1,\cdots,\omega_r,\omega_{r+1})\) by \(\zeta_r'' (0;w;\omega_1,\cdots,\omega_r)\) and Barnes' multiple Bernoulli polynomials ...
openaire   +3 more sources

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Aronia Melanocarpa Extract May Modulate Brain Oscillations and Functional Connectivity: Evidence from EEG Analysis

Namık Kemal Tıp Dergisi
Aim: This study examines the acute and long-term effects of aronia melanocarpa extract (AME) on brain activity using electroencephalography (EEG). The goal is to determine its impact on neural oscillations, functional connectivity, and network efficiency
Aynur MÜDÜROĞLU KIRMIZIBEKMEZ, Alparslan ÖNDER, Mustafa Yasir ÖZDEMİR, İhsan KARA   +3 more
doaj   +1 more source

Immune Effects of γδ T Cells in Colorectal Cancer: A Review

Frontiers in Immunology, 2020
Gamma delta (γδ) T cells can effectively recognize and kill colorectal cancer (CRC) cells, thereby suppressing tumor progression via multiple mechanisms. They also have abilities to exert a protumor effect via secreting interleukin-17 (IL-17). γδ T cells
Rulan Ma, Dawei Yuan, Yizhan Guo, Rong Yan, Kang Li   +4 more
doaj   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source