Results 41 to 50 of about 226,915 (258)

The Perfect Local $ Tb$ Theorem and Twisted Martingale Transforms

, 2012
A local Tb Theorem provides a flexible framework for proving the boundedness of a Calder\'on-Zygmund operator T. One needs only boundedness of the operator T on systems of locally pseudo-accretive functions \{b_Q\}, indexed by cubes.
Lacey, Michael T., Vähäkangas, Antti V.   +1 more
core   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Donaldson-Witten theory and indefinite theta functions

, 2017
We consider partition functions with insertions of surface operators of topologically twisted N=2, SU(2) supersymmetric Yang-Mills theory, or Donaldson-Witten theory for short, on a four-manifold.
Korpas, Georgios, Manschot, Jan
core   +1 more source

Transformation by Iontophoretic Microinjection of DNA: Multiple Integrations Without Tandem Insertions [PDF]

Molecular and Cellular Biology, 1983
DNA transformations of mouse tissue culture cells and mouse embryos were carried out by iontophoretic microinjection of DNA. Iontophoresis involves the use of an externally applied electric current to expel DNA molecules from the injection micropipette into the impaled cell (microelectrophoresis). Restriction analysis of transformants obtained by using
openaire   +2 more sources

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Dynamic Thermal Response of Multiple Parallel Cracks in a Half Plane under General Transient Thermal Loading

Advances in Mathematical Physics
Understanding the dynamic thermal response of materials is crucial for designing effective thermal protection systems, particularly in extreme thermal environments such as transient thermal loading, extremely low/high temperature, etc.
Mahsa Nourazar, Weilin Yang, Zengtao Chen   +2 more
doaj   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Generally Covariant Actions for Multiple D-branes

, 2004
We develop a formalism that allows us to write actions for multiple D-branes with manifest general covariance. While the matrix coordinates of the D-branes have a complicated transformation law under coordinate transformations, we find that these may be ...
A. Connes, Dominic Brecher, Henry Ling, J. De Boer, J. de Boer, J. de Boer, J.M. Maldacena, K. Hashimoto, Kazuyuki Furuuchi, M. Van Raamsdonk, M. Van Raamsdonk, M.R. Douglas, M.R. Douglas, M.R. Douglas, Mark Van Raamsdonk, N. Seiberg, R.C. Myers, S.F. Hassan, T. Banks, V. Sahakian, V. Sahakian, Y. Hyakutake   +21 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

KSAT: Knowledge-infused Self Attention Transformer -- Integrating Multiple Domain-Specific Contexts

, 2022
Domain-specific language understanding requires integrating multiple pieces of relevant contextual information. For example, we see both suicide and depression-related behavior (multiple contexts) in the text ``I have a gun and feel pretty bad about my life, and it wouldn't be the worst thing if I didn't wake up tomorrow''.
Roy, Kaushik, Zi, Yuxin, Narayanan, Vignesh, Gaur, Manas, Sheth, Amit P.   +4 more
openaire   +2 more sources