Results 191 to 200 of about 354,322 (345)

Genomic Analyses of SLAMF7 CAR-T Cells Manufactured by Sleeping Beauty Transposon Gene Transfer for Immunotherapy of Multiple Myeloma [PDF]

, 2019
Csaba Miskey, Maximilian Amberger, Michael Reiser, Sabrina Prommersberger, Julia Beckmann, Markus Machwirth, Hermann Einsele, Michael Hudecek, Halvard Bönig, Zoltán Ivics   +9 more
openalex   +1 more source

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

ChemistryOpen, EarlyView.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel, Mohammed Al‐zharani, Lina M. Alneghery, Noha A. Ahmed, Faris F. Aba Alkhayl, Al Mokhtar Lamsabhi   +5 more
wiley   +1 more source

[Myeloid-derived suppressor cells in peripheral blood of multiple myeloma].

, 2017
Lin Zhou, Shuang Qi, Cheng Yan, Huimin Jin, Jie Xu, Li Ma, Jun Guan, Sheng Xia   +7 more
openalex   +2 more sources

5PSQ-053 Adaptation of prophylaxis against varicella–zoster virus in patients with multiple myeloma [PDF]

, 2019
Ismael Espejo, C Tallon Martinez, Encarna Sánchez, G Hernando Llorente, M Molinero Muñoz, M Saenz de Tejada Lopez, JM Martínez Sesmero   +6 more
openalex   +1 more source

Genetically predicted KIR2DS4 mediate the association between gut microbe K10 and osteoporosis fractures: A mediation Mendelian randomization study

PM&R, EarlyView.
Abstract Background Osteoporosis fractures pose a significant public health concern, leading to substantial morbidity and mortality rates. The emerging evidence on the potential link between gut microbiota, proteins, and osteoporosis fractures suggests a complex relationship that warrants further investigation.
Qiong Wang, Qing Kuang, Cheng Chen, Binru Wang, Wei Xiang, Xinming Li, Jianjiao Mou   +6 more
wiley   +1 more source

CELMoD-antibody conjugates unlock a CD38 feedback loop in multiple myeloma. [PDF]

Acta Pharm Sin B
Jin J.
europepmc   +1 more source

Recent Progress in the Development of Metal‐Based Radiosensitizations for Cancer Therapy: A Review

Rare Metals, EarlyView.
ABSTRACT Radiotherapy (RT) remains an indispensable means in cancer treatment; however, its therapeutic efficacy is often limited by tumor radioresistance and side effect of damage to healthy tissue. The advances in nanotechnology have propelled metal radiosensitizers to forefront of precision medicine.
Xiao‐Xia Wu, Ding‐Hu Zhang, Chuan Hu, Yi‐Nan Ding, Kun Chen, Yi Jiang, Jun Luo, Fei Cao, Wei‐Yuan Hao, Bin‐Yan Zhong, Jie Lin, Dong Xu, Jia‐Ping Zheng   +12 more
wiley   +1 more source

Adipokines as Prognostic Biomarkers in Multiple Myeloma: A Case-Control Study. [PDF]

Medicina (Kaunas)
Obajed Al-Ali N, Csige D, Pinczés LI, Farkas K, Rebenku I, Domján A, Panyi G, Szekanecz Z, Szűcs G, Illés Á, Váróczy L.   +10 more
europepmc   +1 more source

Nanomedicine Meets Immunotherapy: Transforming Chimeric Antigen Receptor T Cell Treatment for Solid Tumors

Small Science, EarlyView.
This review highlights recent advances in nanomedicine that enhance chimeric antigen receptor (CAR) T cell therapy against solid tumors. It discusses key barriers to CAR T cell efficacy and outlines nanotechnology‐based strategies to improve tumor targeting, remodel the immunosuppressive microenvironment, and integrate nanomaterials into CAR T cell ...
Stephen O’Rourke, Nuo Xu, Hongjun Wang, Hexin Chen   +3 more
wiley   +1 more source

Moderate-Severe Thrombocytopenia Portends Poor Outcomes in Multiple Myeloma. [PDF]

EJHaem
Ferri GM, Yildirim C, Do NV, Brophy MT, Munshi NC, Edwards CV, Fillmore NR.   +6 more
europepmc   +1 more source