Results 171 to 180 of about 51,890 (248)
Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research
Mass Spectrometry Reviews, EarlyView.Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik +3 more
wiley +1 more source
Medicine Advances, EarlyView.This study identified shared molecular alterations between lung adenocarcinoma (LUAD) and ischemic stroke (IS) through integrative transcriptomic analysis of TCGA‐LUAD and GSE146882 datasets, revealing a four‐gene diagnostic signature (LDHA, NME4, SLC25A39, and SLC7A5) with high accuracy across both diseases. Among these, LDHA was further identified as
Jin Xie +6 more
wiley +1 more source
Neuroprotection, EarlyView.Abstract Prime editing, a novel clustered regularly interspaced short palindromic repeats (CRISPR)‐based technology, fuses a reverse transcriptase (RT) to an engineered CRISPR‐associated protein 9 (Cas9) and uses a prime editing guide RNA (pegRNA)‐encoded template.
Tianshan Ji +4 more
wiley +1 more source
A Review of Bioarcheological Investigations in Iron Age Cambodia
International Journal of Osteoarchaeology, EarlyView.ABSTRACT Archeological research within Cambodia is quite extensive, with significant projects led by both Cambodian archeologists and international researchers alike. Many of these projects have uncovered human skeletal remains. This article reviews archeological human skeletal studies in Cambodia, synthesizing published and unpublished data, primarily
Sophorn Nhoem +3 more
wiley +1 more source
Multiple myeloma remains an incurable disease, despite the development of numerous drug classes and combinations that have contributed to improved overall survival.
International Myeloma Working Group
core
Targeting fibrosis in the treatment of lower urinary tract dysfunction
The Journal of Pathology, EarlyView.Abstract Benign prostatic hyperplasia (BPH) is a widely prevalent age‐associated disease that is the main contributor to lower urinary tract dysfunction (LUTD) in aging men. Although prostate fibrosis has been recognized as a contributor to BPH pathophysiology, there are not any clinically available therapeutics that target this aspect of disease ...
Ajinkya R Limkar +6 more
wiley +1 more source
Precision Medical Sciences, EarlyView.Multipathway schematic of endocrine therapy–induced cancer‐related fatigue. Endocrine interventions trigger four interacting mechanisms—neuroendocrine dysregulation, systemic inflammation, energy‐metabolic failure, and psycho‐behavioral amplification—that culminate in the multidimensional CRF phenotype.
Jiajing Jiang +7 more
wiley +1 more source
Phytotherapy Research, EarlyView.Schematic summary of the experimentally supported mechanism of DHL in hepatocellular carcinoma. Dehydrocostus lactone (DHL), a sesquiterpene lactone derived from Aucklandia lappa, directly engages protein tyrosine kinase 7 (PTK7), as supported by molecular docking, CETSA, and DARTS assays.
Xiwen Fan +8 more
wiley +1 more source
Mathematical modeling and analysis for multiple myeloma treatment
Multiple myeloma (MM) is a cancer of plasma cells in the bone marrow, where abnormal plasma cells overproduce a harmful antibody, M protein, leading to conditions such as bone lesions, renal dysfunction, and hypercalcemia. Although incurable, controlling
Watt, Kenton
core