Results 41 to 50 of about 4,750,590 (259)

Identification of disease-related aberrantly spliced transcripts in myeloma and strategies to target these alterations by RNA-based therapeutics

Blood Cancer Journal, 2023
Novel drug discoveries have shifted the treatment paradigms of most hematological malignancies, including multiple myeloma (MM). However, this plasma cell malignancy remains incurable, and novel therapies are therefore urgently needed.
Daisuke Ogiya, Zuzana Chyra, Sigitas J. Verselis, Morgan O’Keefe, Jacquelyn Cobb, Ivane Abiatari, Srikanth Talluri, Anjana Anilkumar Sithara, Teru Hideshima, Michael P. Chu, Roman Hájek, David M. Dorfman, Linda M. Pilarski, Kenneth C. Anderson, Sophia Adamia   +14 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Osteoclast Immunosuppressive Effects in Multiple Myeloma: Role of Programmed Cell Death Ligand 1

Frontiers in Immunology, 2018
Immunomodulatory drugs and monoclonal antibody-based immunotherapies have significantly improved the prognosis of the patients with multiple myeloma (MM) in the recent years.
Yu-Tzu Tai, Shih-Feng Cho, Shih-Feng Cho, Shih-Feng Cho, Kenneth C. Anderson   +4 more
doaj   +1 more source

Harnessing the Immune System Against Multiple Myeloma: Challenges and Opportunities

Frontiers in Oncology, 2021
Multiple myeloma (MM) is an incurable malignancy of plasma cells that grow within a permissive bone marrow microenvironment (BMM). The bone marrow milieu supports the malignant transformation both by promoting uncontrolled proliferation and resistance to
Leona Yamamoto, Nicola Amodio, Annamaria Gulla, Kenneth Carl Anderson   +3 more
doaj   +1 more source

The monoclonal antibody nBT062 conjugated to maytansinoids has potent and selective cytotoxicity against CD138 positive multiple myeloma cells _in vitro_ and _in vivo_ [PDF]

, 2008
CD138 (Syndecan1) is highly expressed on multiple myeloma (MM) cells. In this study, we examined the anti-MM effect of murine/human chimeric CD138-specific monoclonal antibody (mAb) nBT062 conjugated with highly cytotoxic maytansinoid derivatives _in ...
Christoph Uherek, Kenneth C. Anderson, Giulia Perrone, Yu-Tzu Tai, Paul Richardson, Hiroshi Ikeda, Robert J. Lutz, Nikhil C. Munshi, Tanyel Kiziltepe, Hiroshi Yasui, Mariateresa Fulciniti, Frank Osterroth, Yutaka Okawa, Silkie Aigner, Teru Hideshima, Loredana Santo, Sonia Vallet, Diana Cristea, Noopur S. Raje, Samantha Pozzi, Benjamin Dälken   +20 more
core  

Using cell‐free RNA to identify B‐ and T‐cell clonality for diagnosis and monitoring of B‐ and T‐cell neoplasms

FEBS Open Bio, EarlyView.
Using peripheral blood for determining B‐cell or T‐cell clonality is more reliable when we use cell‐free RNA (cfRNA) because cells release blood significantly more RNA than DNA. Next‐generation sequencing (NGS) of cfRNA allows us to evaluate fragment cfRNA and evaluate clonality reliably without the need for prior determination of the specific dominant
Adam Albitar, Sally Agersborg, Ahmed Charifa, Pooja Phull, Noa Biran, David Vesole, Harsh Parmar, Andrew Pecora, Andrew Ip, Andre Goy, David Siegel, Maher Albitar   +11 more
wiley   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

Charting Morphotoxicity With Complementary Embryo Models

Advanced Healthcare Materials, EarlyView.
Three human embryo models of the peri‐implantation stages are exposed to a library of compounds. The (toxic) effects of the compounds are analyzed through automated image analysis pipelines. By evaluating the differential responses of the embryo models, this study underscores the importance of testing complementary embryo models to achieve robust and ...
Dorian G. Luijkx, Pauline L. Balder, Romy M. L. Verhagen, Vinidhra Shankar, Barry Jutten, Pinak Samal, Timo Rademakers, Clemens A. van Blitterswijk, Stefan Giselbrecht, Erik J. Vrij   +9 more
wiley   +1 more source

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source

Comprehensive molecular profiling of multiple myeloma identifies refined copy number and expression subtypes. [PDF]

Multiple myeloma is a treatable, but currently incurable, hematological malignancy of plasma cells characterized by diverse and complex tumor genetics for which precision medicine approaches to treatment are lacking.
Cho, Hearn Jay, Jewell, Scott, DeRome, Mary, Donnelly, Andrea, Christofferson, Austin W., Aldrich, Jessica, Nasser, Sara, Boateng, Martin, Carpten, John, Rohrer, Daniel, Cho, Hearn, Orloff, Gregory, Cuyugan, Lori, Auclair, Daniel, Livermore, Brianne, McBride, Kyle, Jakubowiak, Andrzej, Helland, Adrienne, Reiman, Rebecca, Stumph, Jennifer, Anderson, Kenneth, Wolf, Jeffrey, Jagannath, Sundar, Usmani, Saad Z., Turner, Bryce, Liang, Winnie, Berdeja, Jesus, Skerget, Sheri, Stephenson, Kristi, Kidd, Pam, Adkins, Jonathan R., Vij, Ravi, Miller, Chase, Keats, Jonathan J., Niesvizky, Ruben, Anderson, Kenneth C., Usmani, Saad, Adkins, Jonathan, Aldrich, Jessica L., Kyman, Shari, DAgostino, Mattia, Jakubowiak, Andrzej J., Keats, Jonathan, Chari, Ajai, Kirchhoff, Meghan, Liang, Winnie S., Benard, Brooks, Kurdoglu, Ahmet, Tassone, Erica, Berdeja, Jesús G., D’Agostino, Mattia, Christofferson, Austin, Yellapantula, Venkata, Collison, Kimberly, Zaugg, Barbara, Siegel, David S., Jewell, Scott D., Lonial, Sagar, Levy, Moshe, Gutierrez, Norma, Legendre, Christophe, Gamella, Manuela, Penaherrera, Daniel, Toone, Maureen, McDonald, Jackie, Siegel, David, Washington, Megan, Rohrer, Daniel C., Rogers, Jennifer, Gutiérrez, Norma Carmen, Blanski, Alex, Craig, David, Liles, Darla   +72 more
core   +1 more source