Results 51 to 60 of about 51,890 (248)

Multiple Myeloma Case Developed During the Use of the Teriparatide

, 2022
Recombinant human parathyroid hormone (1-34) (rhPTH 1-34), teriparatide, is a class of anabolic therapy for treating severe osteoporosis. Although plasma cell dyscrasias are excluded among the known side effects of teriparatide treatment, their ...
Mustafa Ünübol, İrfan Yavaşoğlu, Zehra Erdemir, Ayşe İyiyapıcı Ünübol, Esra Ercan Aktekin, Engin Güney   +5 more
core   +1 more source

Aptamer‐Based Delivery Systems for VEGF and NGF Modulation in Ocular Therapies

Advanced Healthcare Materials, EarlyView.
Aptamer‐based delivery systems targeting NGF and VEGF hold significant potential for precise and sustained treatment of complex diseases affecting both the anterior and posterior segments of the eye. This review critically summarizes current strategies for NGF and VEGF delivery as well as VEGF sequestration, providing a clinical perspective on how ...
Nadine Best, Gizem Karabiyik, Gerd Geerling, Sarah Barbara Zwingelberg, Gregor Lang, Martin Humenik   +5 more
wiley   +1 more source

Repair of DNA interstrand crosslinks as a mechanism of clinical resistance to melphalan in multiple myeloma

, 2002
Melphalan is widely used as a preparative agent in patients with multiple myeloma (MM) undergoing autologous stem cell transplantation (SCT). Although disease relapse is the major cause of death after a melphalan-conditioned autograft, the mechanism ...
Mahendra, P, Hochhauser, D, Hockhauser, D, Spanswick, VJ, Shankaranarayana, P, Mahendra, Premini, Hughes, RG, Craddock, Charles; id_orcid, Craddock, C, Sekhar, M, Hartley, JA, Spanswick, V   +11 more
core   +1 more source

Microgel‐Based 3D Bioprinting: A Convergent Strategy Integrating Material Design, Jamming Dynamics, and Biological Function

Advanced Healthcare Materials, EarlyView.
Microgel‐based 3D printed constructs represent a compelling and versatile innovation for engineering architecturally complex, dynamically remodelable, and biocompatible structures with high structural fidelity and bioactivity. By integrating material design, biofabrication, and biological function, these systems enable the development of adaptive ...
Elena Ghighină, Andreea Ioana Dinu, Jana Ghițman   +2 more
wiley   +1 more source

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Epigenetic regulation of CD38/CD48 by KDM6A mediates NK cell response in multiple myeloma

Nature Communications
Anti-CD38 monoclonal antibodies like Daratumumab (Dara) are effective in multiple myeloma (MM); however, drug resistance ultimately occurs and the mechanisms behind this are poorly understood.
Jiye Liu, Lijie Xing, Jiang Li, Kenneth Wen, Ning Liu, Yuntong Liu, Gongwei Wu, Su Wang, Daisuke Ogiya, Tian-Yu Song, Keiji Kurata, Johany Penailillo, Eugenio Morelli, Tingjian Wang, Xiaoning Hong, Annamaria Gulla, Yu-Tzu Tai, Nikhil Munshi, Paul Richardson, Ruben Carrasco, Teru Hideshima, Kenneth C. Anderson   +21 more
doaj   +1 more source

CD229 CAR T cells eliminate multiple myeloma and tumor propagating cells without fratricide

Nature Communications, 2020
CD229 is expressed on the surface of multiple myeloma cells, as well as B and T lymphocytes. Here, the authors engineer CD229-specific CAR T cells and, using patient samples and mouse models, show that treatment with these cells reduces tumour burden and
Sabarinath V. Radhakrishnan, Tim Luetkens, Sandra D. Scherer, Patricia Davis, Erica R. Vander Mause, Michael L. Olson, Sara Yousef, Jens Panse, Yasmina Abdiche, K. David Li, Rodney R. Miles, William Matsui, Alana L. Welm, Djordje Atanackovic   +13 more
doaj   +1 more source

Investigation of the intrinsic mechanism of drug resistance in multiple myeloma [PDF]

, 2011
The focus of this thesis was to evaluate the mechanisms whereby myeloma cells develop intrinsic resistance with a focus on resistance in the context of bortezomib treatment.
Ooi, Melissa
core  

Comprehensive molecular profiling of multiple myeloma identifies refined copy number and expression subtypes. [PDF]

Multiple myeloma is a treatable, but currently incurable, hematological malignancy of plasma cells characterized by diverse and complex tumor genetics for which precision medicine approaches to treatment are lacking.
Cho, Hearn Jay, Jewell, Scott, DeRome, Mary, Donnelly, Andrea, Christofferson, Austin W., Aldrich, Jessica, Nasser, Sara, Boateng, Martin, Carpten, John, Rohrer, Daniel, Cho, Hearn, Orloff, Gregory, Cuyugan, Lori, Auclair, Daniel, Livermore, Brianne, McBride, Kyle, Jakubowiak, Andrzej, Helland, Adrienne, Reiman, Rebecca, Stumph, Jennifer, Anderson, Kenneth, Wolf, Jeffrey, Jagannath, Sundar, Usmani, Saad Z., Turner, Bryce, Liang, Winnie, Berdeja, Jesus, Skerget, Sheri, Stephenson, Kristi, Kidd, Pam, Adkins, Jonathan R., Vij, Ravi, Miller, Chase, Keats, Jonathan J., Niesvizky, Ruben, Anderson, Kenneth C., Usmani, Saad, Adkins, Jonathan, Aldrich, Jessica L., Kyman, Shari, DAgostino, Mattia, Jakubowiak, Andrzej J., Keats, Jonathan, Chari, Ajai, Kirchhoff, Meghan, Liang, Winnie S., Benard, Brooks, Kurdoglu, Ahmet, Tassone, Erica, Berdeja, Jesús G., D’Agostino, Mattia, Christofferson, Austin, Yellapantula, Venkata, Collison, Kimberly, Zaugg, Barbara, Siegel, David S., Jewell, Scott D., Lonial, Sagar, Levy, Moshe, Gutierrez, Norma, Legendre, Christophe, Gamella, Manuela, Penaherrera, Daniel, Toone, Maureen, McDonald, Jackie, Siegel, David, Washington, Megan, Rohrer, Daniel C., Rogers, Jennifer, Gutiérrez, Norma Carmen, Blanski, Alex, Craig, David, Liles, Darla   +72 more
core   +1 more source