Results 61 to 70 of about 91,752 (312)

Multiple Objective Programming Support

, 1998
This paper gives a brief introduction into multiple objective programming support. We will overview basic concepts, formulations, and principles of solving multiple programming problems.To solve those problems requires the the intervention of a decision ...
Korhonen, P.
core   +1 more source

Time Dependency in Multiple Objective Dynamic Programming

Journal of Mathematical Analysis and Applications, 1993
The paper presents a theoretical and algorithmic development for the problem of path planning in networks including multiple time dependent costs on the links. The goal is to compute all nondominated paths in an efficient computational procedure. A general network, not assumed to be acyclic is considered.
Kostreva, M.M., Wiecek, M.M.
openaire   +1 more source

A data-driven optimization approach for automated reviewer assignment using natural language processing

Intelligent Systems with Applications
In many settings, such as project or publication selection, expert reviewers play a pivotal role, as their assessments serve as the primary basis for determining a project's prospective value. The effectiveness of matching and assigning qualified experts
Meltem Aksoy, Seda Yanik, Mehmet Fatih Amasyali   +2 more
doaj   +1 more source

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

Multiple-objective Load Optimization Control Based on Fuzzy Dynamic Programming

, 2015
Direct load control DLC is one of the important means for demand response in the electricity market. Combined with the features of direct load control strategy, this paper takes electricity benefit increase, systems peak load reduction as well as ...
Chen F(陈凤), Zeng P(曾鹏), Zang CZ(臧传治)   +2 more
core  

Eliminating congestion of decision-making units using inverse data envelopment analysis [PDF]

Journal of Mahani Mathematical Research
This survey proposes a new application of the inverse data envelopment analysis (InvDEA) in the problem of merging decision-making units (DMUs) to improve the performance of DMUs by removing congestion.
Tahereh Shahsavan, Masoud Sanei, Ghasem Tohidi, Farhad Hosseinzadeh Lotfi, Saeid Ghobadi   +4 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, Volume 20, Issue 6, Page 1429-1452, June 2026.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Stochastic Approach versus Multiobjective Approach for Obtaining Efficient Solutions in Stochastic Multiobjective Programming Problems [PDF]

In this work, we deal with obtaining efficient solutions for stochastic multiobjective programming problems. In general, these solutions are obtained in two stages: in one of them, the stochastic problem is transformed into its equivalent deterministic ...
Mª del Mar Muñoz, Emilio Cerdá, Rafael Caballero, Lourdes Rey   +3 more
core  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, Volume 20, Issue 6, Page 1398-1419, June 2026.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, Volume 20, Issue 6, Page 1626-1642, June 2026.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source