Results 81 to 90 of about 91,752 (312)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Using Multiple Objective Programming in a Dairy Cow Breeding Program
Journal of Dairy Science, 2001 Multiple-objective programming was used to examine the effects various objectives had on the optimal portfolio of sires chosen for a given breeding problem in a Jersey cow dairy herd. It was assumed that the dairy producer had the following three objectives in the breeding decision: to maximize Net Merit, to minimize inbreeding, and to minimize total ...
P R, Tozer, J R, Stokes
openaire +2 more sources
A goal programming approach in order to minimize logistic costs and maximize service level in supply chain [PDF]
Muṭāli̒āt-i Mudīriyyat-i Ṣan̒atī, 2015 Performance of supply chain usually is measured through multiple-criteria. In this paper, an integrated model is proposed to plan a supply chain with three-echelons of supply, production, and distribution considering both logistic costs and service level,
Kaveh Khalili,, Maryam Tajik Khavh
doaj
Ain Shams Engineering Journal, 2019 The latest advancement in the technology, including the integration of the renewable energy resources, has become a recent trend in the power system infrastructure. Although, this can bring many benefits, excessive integration without proper planning may
S.A. Syed Mustaffa +3 more
doaj +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
, 2011 This article presents an algorithm for multi-objective optimization that blends together a number of heuristics. A population of agents combines heuristics that aim at exploring the search space both globally and in a neighbourhood of each agent.
Vasile, M. +3 more
core +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
A robust-solution-based methodology to solve multiple-objective problems with uncertainty
, 2009 This paper presents the formulation and evaluation of a methodology to solve multiple-objective problems in the presence of uncertainty based on robustness.
Sevaux, Marc +3 more
core +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Multiobjective route finding in a multimode transportation network by NSGA-II
Journal of Engineering and Applied ScienceRoute finding is an everyday challenge for urban residents. While many route planner applications exist, they cannot find suitable routes based on user preferences. According to user preferences, routing in a multimode urban transportation network can be
Hamed Faroqi
doaj +1 more source