Results 91 to 100 of about 9,918,984 (250)
The political districting of Kuwait: Heuristic approaches
Kuwait Journal of Science, 2015 This paper models the political districting of Kuwait as a multiple objective combinatorialoptimization problem, where each political system is assessed in terms of population andvoting equity, geographical contiguity, and social, religious, ethnic ...
SHAFIQAH ALAWADHI, RYM MAHALLA
doaj
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
MULTIPLE OPTIMAL SOLUTIONS IN QUADRATIC PROGRAMMING MODELS [PDF]
The problem of determining whether quadratic programming models possess either unique or multiple optimal solutions is important for empirical analyses which use a mathematical programming framework.
Paris, Quirino
core
Multiple Objective Linear Fractional Programming
This paper presents a simplex-based solution procedure for the multiple objective linear fractional programming problem. By (1) departing slightly from the traditional notion of efficiency and (2) augmenting the feasible region as in goal programming ...
Ralph E. Steuer +1 more
core +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Multiple goals in farmers’ decision making: The case of sheep farming in Western Greece [PDF]
Management strategies and performance differ among farmers, as a result of different, multiple and often conflicting goals. Many approaches to building farm level models that incorporate multiple goals have been developed over the years, most of which ...
Rozakis, Stelios +2 more
core
Sausage Blending Using Multiple Objective Linear Programming
Single objective cost minimization linear programming models are used as computerized decision-aids in sausage manufacturing (hot dogs, bologna, salami, etc.). However, sausage blending is clearly a problem with multiple conflicting criteria (cost, color,
Ralph E. Steuer
core +1 more source
Preferences in evolutionary multiple criteria decision making optimisation [PDF]
, 2003 Despite the number of approaches established for Multiple Criteria Optimisation Problems, few of them have been developed for the decision making process.
Duenas, Alejandra
core +2 more sources
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source