Results 41 to 50 of about 354,631 (302)

Hyperferritinemic sepsis, macrophage activation syndrome, and mortality in a pediatric research network: a causal inference analysis

Critical Care, 2023
Background One of five global deaths are attributable to sepsis. Hyperferritinemic sepsis (> 500 ng/mL) is associated with increased mortality in single-center studies. Our pediatric research network’s objective was to obtain rationale for designing anti-
Zhenziang Fan, Kate F. Kernan, Yidi Qin, Scott Canna, Robert A. Berg, David Wessel, Murray M. Pollack, Kathleen Meert, Mark Hall, Christopher Newth, John C. Lin, Allan Doctor, Tom Shanley, Tim Cornell, Rick E. Harrison, Athena F. Zuppa, Katherine Sward, J. Michael Dean, H. J. Park, Joseph A. Carcillo   +19 more
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Death due to COVID‐19 in a patient with diabetes, epilepsy, and gout comorbidities

Clinical Case Reports, 2021
There is evidence of increased incidence, rapid progression, and poor prognosis of COVID‐19 in patients with underlying comorbidities such as diabetes and epilepsy. Developing effective treatment regimens for COVID‐19 patients with multiple comorbidities
Amir Reza Safdarian, Kaveh Momenzadeh, Farima Kahe, Pooya Farhangnia, Nima Rezaei   +4 more
doaj   +1 more source

Neuroblastoma with neonatal cardiogenic shock and multiple‐organ failure: A rare association [PDF]

, 2023
Noémie de Cacqueray, Lara Mayrand, L. Vaccaroni, Stefania Querciagrossa, Cécile Lozach, Paul Vergnaud, Yasmine Benadjaoud, Gudrun Schleiermacher, Daniel Orbach, Sabine Sarnacki   +9 more
openalex   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Dealing with multiple organ failure

Revista Cubana de Cardiología y Cirugía Cardiovascular, 2014
One of the greatest challenges faced by physicians in an ICU is multiple organ failure, syndrome that shows unclear multifactor etiopathogenesis, varied clinical picture, few early diagnosis devices, high mortality rate and non-specific treatment so far.
Karel Morlans Hernández, José Santos Gracia, Carlos M. González-Prendes Álvarez, Fausto Rodríguez Salgueiro, Bruno García Mendive, Humberto Saínz   +5 more
doaj  

Polytrauma patients with infections associated with health care admitted to an intensive care unit

Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2021
Background: in the treatment of traumatized patients, sepsis with subsequent multiple organ failure is the main non-neurological cause of death in those who survive the first 48 hours after trauma.Objective: to characterize polytrauma patients with ...
Runiel Tamayo-Pérez, Ania Martínez-Utria, Zunilda Leticia Bello-Fernández, Yilian Hernández-Ferrales, Yaritza Isabel Hernández-Díaz   +4 more
doaj  

The therapeutic efficacy of adjunct therapeutic plasma exchange for septic shock with multiple organ failure: a single-center experience

Critical Care, 2020
Background Sepsis remains a common condition with high mortality when multiple organ failure develops. The evidence for therapeutic plasma exchange (TPE) in this setting is promising but inconclusive.
Philip D. Keith, Adam H. Wells, Jeremy Hodges, Stephen H. Fast, Amber Adams, L. Keith Scott   +5 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Primer caso de ehrlichiosis monocítica humana reportado en Colombia

Infectio, 2014
La ehrlichiosis es una infección no reconocida ni sospechada en nuestro medio, sin embargo, ciertas características epidemiológicas hacen que deba pensarse en esta entidad a la hora de abordar a un paciente con un cuadro clínico compatible.
Alicia Hidrón Botero, Fabián Muñoz Ramirez, Juliana Vega Miranda   +2 more
doaj   +1 more source