Results 51 to 60 of about 773,408 (302)

The clinical significance of the arterial ketone body ratio as an early indicator of graft viabilityin human liver transplantation [PDF]

, 1991
Arterial ketone body ratio (AKBR) was measured sequentially in 84 liver transplantations (OLTx). These transplantation procedures were classified into 3 groups with respect to graft survival and patient condition at the end of the first month (Group A ...
Asonuma, K, Okamoto, R, Ozawa, K, Selby, R, Starzl, TE, Takaya, S, Todo, S, Yamamoto, Y, Yokoyama, T   +8 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Polytrauma patients with infections associated with health care admitted to an intensive care unit

Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2021
Background: in the treatment of traumatized patients, sepsis with subsequent multiple organ failure is the main non-neurological cause of death in those who survive the first 48 hours after trauma.Objective: to characterize polytrauma patients with ...
Runiel Tamayo-Pérez, Ania Martínez-Utria, Zunilda Leticia Bello-Fernández, Yilian Hernández-Ferrales, Yaritza Isabel Hernández-Díaz   +4 more
doaj  

The therapeutic efficacy of adjunct therapeutic plasma exchange for septic shock with multiple organ failure: a single-center experience

Critical Care, 2020
Background Sepsis remains a common condition with high mortality when multiple organ failure develops. The evidence for therapeutic plasma exchange (TPE) in this setting is promising but inconclusive.
Philip D. Keith, Adam H. Wells, Jeremy Hodges, Stephen H. Fast, Amber Adams, L. Keith Scott   +5 more
doaj   +1 more source

Shock volume: Patient-specific cumulative hypoperfusion predicts organ dysfunction in a prospective cohort of multiply injured patients [PDF]

, 2018
BACKGROUND: Multiply injured patients are at risk of developing hemorrhagic shock and organ dysfunction. We determined how cumulative hypoperfusion predicted organ dysfunction by integrating serial Shock Index measurements. METHODS: In this study,
Bell, Teresa M., Gaski, Greg E., McCarroll, Tyler, McKinley, Todd O., Metzger, Cameron, Savage, Stephanie A., Zarzaur, Ben L.   +6 more
core   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Dealing with multiple organ failure

Revista Cubana de Cardiología y Cirugía Cardiovascular, 2014
One of the greatest challenges faced by physicians in an ICU is multiple organ failure, syndrome that shows unclear multifactor etiopathogenesis, varied clinical picture, few early diagnosis devices, high mortality rate and non-specific treatment so far.
Karel Morlans Hernández, José Santos Gracia, Carlos M. González-Prendes Álvarez, Fausto Rodríguez Salgueiro, Bruno García Mendive, Humberto Saínz   +5 more
doaj  

Early Expression of Pro- and Anti-Inflammatory Cytokines in Left Ventricular Assist Device Recipients With Multiple Organ Failure Syndrome [PDF]

To assess whether the combined evaluation of total Sequential Organ Failure Assessment (t-SOFA) score and pro- and anti-inflammatory cytokine profiles early after left ventricular assist device (LVAD) implant discriminates patients at high risk for ...
Caruso, Raffaele
core   +3 more sources

Multiple organ failure diagnosis using adverse events and neural networks [PDF]

, 2006
In the past years, the Clinical Data Mining arena has suffered a remarkable development, where intelligent data analysis tools, such as Neural Networks, have been successfully applied in the design of medical systems.
Cortez, Paulo, Gomes, Lopes, Neves, José, Santos, Manuel Filipe, Silva, Álvaro   +4 more
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source