Results 51 to 60 of about 354,631 (302)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

NEONATAL MULTIPLE ORGAN FAILURE AFTER PERINATAL ASPHYXIA

Slovenska pediatrija
Asphyxia is a combination of hypoxia and hypoperfusion that impairs gas exchange and the availability of energy substrates in tissues, causing tissue acidosis. Despite advances in perinatal care perinatal asphyxia remains a common condition that can have
Hana Umek, Gregor Nosan
doaj   +1 more source

Multiple organ failure after trauma [PDF]

BMJ, 1996
The concept of multiple organ failure dates back to the 1970s,1 but it has recently been redefined as “the progressive (and sometimes sequential) dysfunction of physiologic systems in the presence of a clinical picture of systemic sepsis.”2 Multiple organ failure is often caused by the “systemic inflammatory response syndrome” (SIRS).3 A patient who ...
Saadia, R., Lipman, J.
openaire   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

The intensive care unit admission predicting the factors of late complications in trauma patients: A prospective cohort study

Archives of Trauma Research, 2019
Background: Organ failure (OF) and sepsis are important causes of late death in trauma. Previous studies reported the methods that could predict OF at the time of patient arrival.
Osaree Akaraborworn, Onuma Chaiwat, Sunisa Chatmongkolchart, Kaweesak Chittawatanarat, Chanatthee Kitsiripant, Sunthiti Morakul, Thammasak Thawitsri, Petch Wacharasint, Sujaree Poopipatpab, Waraporn Chau-In, Chaiyapruk Kusumaphanyo   +10 more
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Postoperative hyperthermia-induced multiple organ failure in a child with Down syndrome: a case report

Journal of Medical Case Reports, 2022
Background Psychological stress has been reported to cause hyperthermia. Persistent excessive hyperthermia can, in turn, cause hypercytokinemia and organ damage.
Keiichi Koizumi, Fuminori Numano, Tomoko Tandou, Ken Takada, Minako Hoshiai, Noboru Oyachi   +5 more
doaj   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

Multiple organ failure in septic patients

Brazilian Journal of Infectious Diseases, 2001
Multiple organ failure (MOF) is the main cause of death in ICUs, especially affecting septic patients. It is strongly related to number of systems with failure, type of system involved, risk factors such as age, previous chronic diseases, delayed or ...
Bilevicius Elizabeth, Dragosavac Desanka, Dragosavac Sanja, Araújo Sebastião, Falcão Antonio L.E., Terzi Renato G.G.   +5 more
doaj  

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source