Results 41 to 50 of about 12,940,323 (262)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Three Different Primary Cancers, Including Breast, Esophagus, and Renal in a Single Patient: A Case Report

Clinical Case Reports
There are different combinations of multiple primary cancers; however, the combination of breast, esophagus, and renal cancer has been reported in a few cases.
Amir Alinejad Khorram, Mohammad Soleimani, Ali Amani‐Beni, Tahmineh Mollasharifi, Reza Amani‐Beni, Farzad Allameh   +5 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Options for early breast cancer follow-up in primary and secondary care : a systematic review [PDF]

, 2012
Background Both incidence of breast cancer and survival have increased in recent years and there is a need to review follow up strategies. This study aims to assess the evidence for benefits of follow-up in different settings for women who have had ...
Peter Donnelly, Dunn, Janet A., Dunn Janet, Donnelly Peter, Frances Taggart, Taggart Frances, Taggart, Frances M., Donnelly, Peter K., Janet Dunn   +8 more
core   +2 more sources

Susceptibility of Multiple Primary Cancers in Patients With Head and Neck Cancer: Nature or Nurture?

Frontiers in Oncology, 2019
Multiple primary cancers (MPCs) are major obstacles to long-term survival in head and neck cancer (HNSCC), however, the molecular mechanism underlying multiple carcinogenesis remains unclear.
Wei-long Zhang, Zhuo-li Zhu, Mei-chang Huang, Ya-Jie Tang, Ya-ling Tang, Xin-hua Liang   +5 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Concomitant gastric carcinoma and primary hepatic angiosarcoma in a patient: A case report

Open Life Sciences
Primary hepatic angiosarcoma (PHA) is a rare malignancy, and the occurrence of a dual malignancy involving both gastric cancer (GC) and PHA is even more exceptional. Here, we present a case of a 63-year-old man who complained of hiccups.
Wang Qi, Xie Xuehai, Yang Yinmo, Tian Xiaodong   +3 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

What are multiple primary malignancies? [PDF]

, 2017
Over the past 30 years, the incidence of cancer in Poland has more than doubled. Advances in technology, early diagnosis and improved treatment make more and more malignancies curable. An increase in the survival of cancer patients has also been observed.
Anna Doboszyńska, Doboszyńska, Anna, Romaszko, Anna, Anna Maria Romaszko   +3 more
core   +2 more sources

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source