Results 61 to 70 of about 12,257,906 (257)

Lung cancer epidemiology in North Sardinia, Italy [PDF]

, 2013
Background The aim of this study was to analyze and describe the epidemiological characteristics and trends of lung cancer in North Sardinia, Italy, in the period 1992–2010.
Attene, Federico, Tanda, Francesco, Palmieri, Giuseppe, Cossu, Antonio, Paliogiannis, Panagiotis, Mario Trignano, Trignano, Mario, Francesco Tanda, Giuseppe Palmieri, Cesaraccio, Rosaria, Mario Budroni, Budroni, Mario, Federico Attene, Rosaria Cesaraccio, Panagiotis Paliogiannis, Antonio Cossu   +15 more
core   +1 more source

Clinical and Prognosic Anylasis of 30 Cases with Double Primary Lung Cancer

Chinese Journal of Lung Cancer, 2017
Background and objective Multiple primary lung cancer (MPLC) represents a rare variety of pulmonary malignant tumor while mainly consist of double primary lung cancer (DPLC), but the development of diagnostic techniques promotes the rate diagnosis of it ...
Ziqi WANG, Jingjing HOU, Huijuan WANG, Guowei ZHANG, Zhiyong MA   +4 more
doaj   +1 more source

Macrophage migration inhibitory factor may contribute to the occurrence of multiple primary lung adenocarcinomas

Clinical and Translational Medicine, 2023
Background This study aimed to identify the key genes involved in the development of multiple primary lung cancers. Methods Differential expression analysis was performed, followed by comparing the infiltration levels of 22 immune cell types between ...
Wei Liu, Hao‐Shuai Yang, Fei‐Hang Zhi, Yan‐Fen Feng, Hong‐He Luo, Ying Zhu, Yi‐Yan Lei   +6 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Prognostic significance of folate metabolism polymorphisms for lung cancer. [PDF]

, 2007
Functional nonsynonymous single-nucleotide polymorphisms (nsSNPs) of folate metabolism genes can influence the methylation of tumour suppressor genes, thereby potentially impacting on tumour behaviour.
El Galta, R, Rudd, MF, Houlston, RS, T Eisen, R el Galta, E L Webb, R S Houlston, Matakidou, A, Bridle, H, M F Rudd, H Bridle, Eisen, T, A Matakidou, Webb, EL   +13 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Lung cancer incidence and survival in different ethnic groups in South East England. [PDF]

, 2011
BACKGROUND: This study aimed to examine the incidence and survival of lung cancer patients from several different ethnic groups in a large ethnically diverse population in the United Kingdom.
Davies, E. A.; id_orcid, Jack, RH, Moller, H.; id_orcid, Møller, H, Davies, EA, H Møller, E A Davies, Jack, R. H., R H Jack   +8 more
core   +1 more source

The characteristics and prognosis of different disease patterns of multiple primary lung cancers categorized according to the 8th edition lung cancer staging system

Journal of Cardiothoracic Surgery
Introduction The 8th edition lung cancer staging system was the first to describe the detailed diagnosis and staging of multiple primary lung cancers (MPLC).
Yalong Wang, Lingling Fang, Xiao Hu, Hongliang Wu, Lina Zhou, Qi Xue, Shugeng Gao, Jie He   +7 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source