Results 51 to 60 of about 12,257,906 (257)

Multiple Independent Loci at Chromosome 15q25.1 Affect Smoking Quantity [PDF]

, 2010
Recently, genetic association findings for nicotine dependence, smoking behavior, and smoking-related diseases converged to implicate the chromosome 15q25.1 region, which includes the CHRNA5-CHRNA3-CHRNB4 cholinergic nicotinic receptor subunit genes.
Kaprio J, Pillai S, Martin NG, Saccone NL, Leppert Mark F., Marissa A Ehringer, Wang, Jen C., Witt, Stephanie H., Jensen, Majken K., Sarah H. Stephens, Younghun Han, Peter Kraft, Amos Christopher I., Robert B Weiss, Culverhouse, Robert C., Broderick Peter, Stephanie H Witt, Bierut Laura J., Maria Teresa L, Culverhouse Robert C., Breslau Naomi, Markus M. Nöthen, Gapstur Susan M., Niu, Tianhua, Jen C Wang, Han, Younghun, Witt Stephanie H., Heliovaara, Markku, Thomas J Payne, Andrew C. Heath, Han, Shizhong, Landi MT, Kaprio, Jaakko, Yang BZ, Martin, Nicholas G., Gapstur, Susan M., Kendler KS, Wheeler William, Yufei Wang, Witt SH, Kendler Kenneth S., Wheeler, William, John P. Rice, Kaisu Keskitalo-Vuokko, Hunter David J., Margaret R Spitz, Sarah H Stephens, Ann Schwartz, Spitz, Margaret R., Nancy L. Saccone, Stephens SH, Ming D. Li, Wang JC, Dale S Cannon, Leena Peltonen, David J Hunter, Angela S. Wenzlaff, Andrew C Heath, Caporaso Neil E., Weiss Robert B., Hoft, Nicole R., Payne Thomas J., Neil E. Caporaso, Keskitalo-Vuokko, Kaisu, Landi, Maria Teresa, Breslau N, Sven Cichon, Xiangyang Kong, Breslau, Naomi, Hoft NR, Rietschel Marcella, Stevens VL, Noethen, Markus M., Nöthen, Markus M., Michele L Pergadia, Heliövaara M, Laura J Bierut, Chatterjee N, Michele L. Pergadia, Susan E Short, Robert C Culverhouse, Ina Giegling, Sun Lingwei, Chen X, Kaprio Jaakko, Jensen MK, Stephens Sarah H., Sherva R, Laura J. Bierut, Chen J, Li MD, Heath AC, Nicole R. Hoft, Majken K Jensen, Broderick P, Stevens Victoria L., Martin Nicholas G., Sherva, Richard, Marcella Rietschel, Aggen SH, Nancy L Saccone, Stephens, Sarah H., Peltonen, Leena, Sreekumar Pillai, Cannon Dale S., Sun, Lingwei, Eisen Tim, Mark F. Leppert, Angela S Wenzlaff, Giegling Ina, Bierut LJ, Heliovaara, Marku, Maria Teresa Landi, Pergadia Michele L., Markku Heliövaara, Hunter DJ, Stevens, Victoria L., Kenneth S Kendler, Keskitalo-Vuokko Kaisu, Cannon, Dale S., Ehringer, Marissa A., Schwantes-An Tae-Hwi, Landi, Maria T., Thomas J. Payne, Li Ming D., Peter Broderick, Montgomery GW, Cichon, Sven, Jingchun Chen, John P Rice, Han Younghun, Wang Jen C., Chen Jingchun, Aggen Steven H., Rujescu D, Nicholas G Martin, Rice John P., Pergadia, Michele L., Jennie Z Ma, Yang Bao-Zhu, Eisen T, Marissa A, Nilanjan Chatterjee, Hunter, David J., Madden Pamela A. F., Victoria L. Stevens, Neil E Caporaso, Sun, Juzhong, Steven H Aggen, Nicholas G. Martin, Kenneth S. Kendler, Chen, Xiangning, Cichon S, Landi Maria Teresa, Joel Gelernter, Mark F Leppert, William Wheeler, Gelemter, Joel, Heliövaara Markku, Kraft Peter, Susan E. Short, Saccone Nancy L., Gelernter Joel, Susan M. Gapstur, Chen, Jingchun, Cichon Sven, Wenzlaff AS, Tim Eisen, Heath Andrew C., Madden PA, Pillai, Sreekumar, Robert C. Culverhouse, Lingwei Sun, Chen Xiangning, Rice, John P., Bao-Zhu Yang, Chatterjee, Nilanjan, Richard Houlston, Kraft, Peter, Majken K. Jensen, Rice JP, Shizhong Han, Nicole R Hoft, Pergadia ML, Saccone, Nancy L., Ming D Li, Han Y, Sherva Richard, Montgomery Grant W., Han S, Culverhouse RC, Victoria L Stevens, Kong Xiangyang, Wheeler W, Pamela A F Madden, Dan Rujescu, Ma JZ, Gapstur SM, Steven H. Aggen, Christopher I. Amos, Wenzlaff Angela S., Schwartz Ann, Caporaso NE, Cannon DS, Hoft Nicole R., Short, Susan E., Tianhua Niu, Jen C. Wang, Eisen, Tim, Leppert MF, Wang Yufei, Niu Tianhua, Caporaso, Neil E., Heath, Andrew C., Kong, Xiangyang, Broderick, Peter, Schwartz, Ann, Juzhong Sun, Wenzlaff, Angela S., Weiss, Robert B., Bierut, Laura J., Peltonen L, Rujescu, Dan, Kong X, Yang, Bao-Zhu, Wang, Yufei, Christopher I Amos, Houlston R, Rujescu Dan, Weiss RB, Susan M Gapstur, Houlston Richard, Rietschel M, Schwantes-An, Tae-Hwi, Leppert, Mark F., Giegling, Ina, Richard Sherva, Montgomery, Grant W., Sun L, Amos CI, Gelernter J, Li, Ming D., Schwantes-An TH, Ehringer MA, Ma, Jennie Z., Sun Juzhong, Wang Y, Sun J, Kendler, Kenneth S., Xiangning Chen, Palotie, Leena, Payne TJ, Tae-Hwi Schwantes-An, Jaakko Kaprio, Nöthen Markus M., Naomi Breslau, Marissa A. Ehringer, Aggen, Steven H., Payne, Thomas J., Robert B, Kraft P, Grant W Montgomery, Margaret R. Spitz, Chatterjee Nilanjan, Spitz Margaret R., Houlston, Richard, Keskitalo-Vuokko K, Ma Jennie Z., David J. Hunter, Niu T, Stephanie H. Witt, Short Susan E., Rietschel, Marcella, Nöthen MM, Schwartz A, Grant W, Pillai Sreekumar, Markus M Nöthen, Pamela A. F. Madden, Han Shizhong, Amos, Christopher I., Giegling I, Dale S. Cannon, Grant W. Montgomery, Jensen Majken K., Spitz MR, Peltonen Leena, Gelernter, Joel, Jennie Z. Ma, Pamela A. F, Short SE, Robert B. Weiss, Madden, Pamela A. F., Ehringer Marissa A., Culverhouse, Robert C, Madden, Pamela A.F, Hunter, David, Jensen, Majken, Heath, Andrew C, Bierut, Laura J, Rice, John P, et al.,, Pergadia, Michele L, Short, Susan, Wang, Jen C, Saccone, Nancy L   +305 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Selection of eligible participants for screening for lung cancer using primary care data [PDF]

, 2022
Lung cancer screening is effective if offered to people at increased risk of the disease. Currently, direct contact with potential participants is required for evaluating risk.
Hamilton, W, Ten Haaf, Kevin, Field, JK, Janes, Sam M., Hubbard, RB, Callister, Matthew E., de Koning, Harry, Callister, Matthew Ej, Duffy, Stephen W., Baldwin, DR, Hubbard, Richard B., Kaur, Jaspreet, O’Dowd, Emma L., Baldwin, David R., de Koning, HJ, Duffy, SW, Rawlinson, Janette, ten Haaf, K, Rawlinson, J, de Koning, Harry J., O'Dowd, Emma L., Hamilton, William, Callister, MEJ, Janes, SM, Field, John K., Kaur, J, de Koning, Harry J.; id_orcid, O’Dowd, EL   +27 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Blueprint Of Services For Lung Cancer [PDF]

, 1995
Primary lung cancer is the commonest malignant disease in the developed world, and is the most prevalent form of cancer among men over 65 years. It continues to rise in those aged over 75 years. Mortality from lung cancer is increasing in women.
Doyle, Yvonne G.
core  

Patient with recurrent paratesticular malignant mesothelioma and multiple primary neoplasms [PDF]

Journal of Men's Health
Paratesticular malignant mesothelioma (MM) is a rare tumor frequently associated with asbestos exposure. Therefore, we present an even rarer case of a 78-year-old male patient diagnosed with multiple primary neoplasms, including prostate cancer, lung ...
Kyung Hwan Kim, Yury Lee, Ja Yoon Ku, Hong Koo Ha, Hyun Jun Park   +4 more
doaj   +1 more source

Small nodules (≤ 6 mm in diameter) of multiple primary lung cancers: prevalence and management

Journal of Cardiothoracic Surgery, 2022
Background Synchronous multiple primary lung cancers associated with small non-dominant nodules are commonly encountered. However, the incidence, follow-up, and treatment of small non-dominant tumors have been but little studied.
Hua Cheng, Wen-hao Li, Xiao-jian Li, Hong-cheng Zhong, Xiao-jin Wang, Yu-jing Lin, Xue-guo Liu, Xiang-wen Wu, Qing-dong Cao   +8 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

The genomic and transcriptome characteristics of lung adenocarcinoma patients with previous breast cancer

BMC Cancer, 2022
Background Breast cancer and lung cancer are the top two malignancies in the female population and the number of patients with breast cancer and subsequent primary lung cancer has increased significantly in recent years.
Yan Wang, Wenpeng Song, Sicheng Zhou, Shuai Chang, Junke Chang, Jie Tian, Liming Zhang, Jue Li, Guowei Che   +8 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source