Results 71 to 80 of about 9,892,286 (249)
, 2008 Purpose: For treatment decision and prognostic applications, we evaluated p53/epidermal growth factor receptor (EGFR) somatic aberrations in multiple primary lung cancers to differentiate multifocal tumors from intrapulmonary metastasis.
CHANG, YIH-LEONG;WU, CHEN-TU;HSIAO, CHIN-FU;JOU, YUH-SHAN;LEE, YUNG-CHIE +1 more
core +2 more sources
A Case of Synchronous Multiple Lung Cancers Associated with Hamartoma in the Same Lobe
, 1992 近年,肺癌の診断・治療技術の進歩により,同時性および異時性肺多発癌は稀れではなくなってきた.しかし,同一肺葉内肺多発癌は比較的稀れであり,更に良性腫瘍が混在した場合,その診断は非常に困難である.今回我々は左下葉に3個の腫瘤影を認め,同時性肺多発癌(腺癌,扁平上皮癌)および肺過誤腫であった一手術例を経験した.症例は72才,男性.胸部X線上,左S^6に1個,およびS^に2個の腫瘤影が認められた.手術により,各々扁平上皮癌,腺癌および肺過誤腫の診断が得られ,リンパ節転移,遠隔転移は認められなかった ...
南, 寛行 +5 more
core
Mouse p53-deficient cancer models as platforms for obtaining genomic predictors of human cancer clinical outcomes [PDF]
, 2012 Mutations in the TP53 gene are very common in human cancers, and are associated with poor clinical outcome. Transgenic mouse models lacking the Trp53 gene or that express mutant Trp53 transgenes produce tumours with malignant features in many organs.
Miquel Taron +64 more
core +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Clinical analysis of 41 cases with resected multiple primary lung cancers
Zhongguo aizheng zazhi, 2014 Background and purpose: Multiple primary lung cancers (MPLC) is a rare entity, but recently there has been a gradual increase in the number of patients diagnosed with MPLC. The aim of this study is to investigate the diagnosis, treatment and prognosis of
李营 +5 more
doaj
Identification of Clonality through Genomic Profile Analysis in Multiple Lung Cancers
, 2020 In cases of multiple lung cancers, individual tumors may represent either a primary lung cancer or both primary and metastatic lung cancers. In this study, we investigated the differences between clinical/histopathological and genomic diagnoses to ...
Taichiro Goto +10 more
core +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Medicine Science, 2014 The primary malignant tumors that mostly metastasis to the brain are lung cancers, breast cancers, colorectal cancers, renal cell cancer and malanomas.
Ismail Okan Yildirim, Ayse Aktas
doaj +1 more source
Management of Multiple Primary Lung Cancer in Patients with Centrally Located Early Cancer Lesions [PDF]
, 2010 BackgroundPatients with centrally located early lung cancer (CLELC) are often heavy smokers with a considerably high risk of multiple primary lung cancer (MPLC) lesions; treatment strategies for such patients must preserve the cardiopulmonary function ...
Uchida, Osamu +12 more
core +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source