Results 81 to 90 of about 9,892,286 (249)

Dual malignancy: Carcinoma of different cells in different organs

Journal of Association of Pulmonologist of Tamil Nadu, 2020
Incidence of multiple primary cancers, though uncommon, is being frequently reported nowadays, owing to better diagnostic techniques, the prolonged life span, and the increased incidence of long-term survival of cancer patients. In our case, lung mass in
R Sridhar, R Narasimhan
doaj   +1 more source

Systems for the management of respiratory disease in primary care - an international series: United Kingdom [PDF]

, 2010
INTRODUCTION: The UK National Health Service (NHS) is essentially publicly funded through general taxation. Challenges facing the NHS include the rise in prevalence of long-term conditions and financial pressures.
Allison Worth, Mark Levy, Worth, Allison, Levy, Mark L., Fletcher, Monica, Pinnock, Hilary, Aziz Sheikh, Monica Fletcher, Hilary Pinnock, Pinnock, Hilary; id_orcid, Hoskins, Gaylor, Levy, Mark, Gaylor Hoskins, Sheikh, Aziz, Levy, Mark L   +14 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

A case of synchronous multiple primary lung cancer combining three different histological types

SAGE Open Medical Case Reports
Multiple primary lung cancer is a very rare type of tumour that occurs when two or more primary malignant tumours develop simultaneously or sequentially in the same patient’s lungs.
Wenting Wu, Yinhua Gong, Chengcheng Xu, Dan Shen   +3 more
doaj   +1 more source

Surgical Treatment of Synchronous Multiple Primary Lung Cancers: Experience of 92 Patients

, 2008
Objectives: According to our previous study, the concurrent detection of p53 and epidermal growth factor receptor mutations significantly improves the clonality assessment and impact management of patients with multiple primary lung cancer. Nevertheless,
CHANG, YIH-LEONG;WU, CHEN-TU;LEE, YUNG-CHIE, 張逸良;吳振都;李元麒   +1 more
core  

Deep sequence analysis of non-small cell lung cancer: Integrated analysis of gene expression, alternative splicing, and single nucleotide variations in lung adenocarcinomas with and without oncogenic KRAS mutations [PDF]

, 2012
KRAS mutations are highly prevalent in non-small cell lung cancer (NSCLC), and tumors harboring these mutations tend to be aggressive and resistant to chemotherapy.
David Rossell, Xiaojia eTang, Tang, Xiaojia, Hossain, Asif, Rossell, David, Asha Nair, Jean-Pierre Kocher, Chai, High-Seng, Michael P. Walsh, Asif eHossain, Yan W. Asmann, Baker, Tiffany R., Edith A. Perez, Kalari, Krishna R., Necela, Brian M., Alan P. Fields, High Seng eChai, Xiaojia Tang, Alan P Fields, Leontovich, Alexey A., Carr, Jennifer, Thompson, E. Aubrey, Saurabh Baheti, Kocher, Jean-Pierre, Tiffany R Baker, Younkin, Curtis S., Walsh, Michael P., E. Aubrey Thompson, Jennifer M. Kachergus, Jennifer M Kachergus, Jennifer M Carr, Fields, Alan P., Asmann, Yan W., Krishna R. Kalari, E. Aubrey eThompson, Kachergus, Jennifer M., Steven N Hart, Krishna R Kalari, Jennifer M. Carr, David eRossell, Saurabh eBaheti, Steven N. Hart, Curtis S. Younkin, Zhifu eSun, Edith A Perez, Tiffany Baker, Brian M Necela, Alexey A. Leontovich, Nair, Asha, Perez, Edith A., Sun, Zhifu, Reisman, David N., Jean-Pierre eKocher, Asha eNair, Hart, Steven N., Yan W Asmann, Zhifu Sun, Michael eWalsh, Baheti, Saurabh, David N Reisman, Brian M. Necela, High-Seng Chai, David N. Reisman, Alexey A Leontovich, Asif Hossain, Curtis S Younkin   +65 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Intra-tumour signalling entropy determines clinical outcome in breast and lung cancer. [PDF]

, 2015
The cancer stem cell hypothesis, that a small population of tumour cells are responsible for tumorigenesis and cancer progression, is becoming widely accepted and recent evidence has suggested a prognostic and predictive role for such cells. Intra-tumour
Banerji, CR, Andrew E. Teschendorff (184707), Andrew E Teschendorff, Christopher R S Banerji, Carlos Caldas (1042), Carlos Caldas, Caldas, C, Simone Severini, Teschendorff, AE, Christopher R. S. Banerji (707702), Simone Severini (5662612), Severini, S   +11 more
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Stereotactic body radiation therapy for multiple lung cancers in a patient with six primary cancers: a case report

Journal of Medical Case Reports
Background Surgery is the standard care for patients with early-stage lung cancer, and stereotactic body radiation therapy is an option for those who are medically inoperable or refuse surgery.
Naoko Ishida, Kenji Nagata, Jyunki Fukuda, Yasuo Oguma, Tomonori Hirashima, Kenichi Minami, Yasumasa Nishimura, Yukinori Matsuo   +7 more
doaj   +1 more source